摘要
目的本研究旨在回顾性分析广泛期小细胞肺癌患者临床预后相关因素,指导广泛期小细胞肺癌预后评价。方法2000年1月至2006年12月收治的广泛期小细胞肺癌患者134例,采用Kaplan-Meier和Cox多因素回归模型分析:性别、年龄、一般状况评分、发病时体质量减轻、血清乳酸脱氢酶水平、血清碱性磷酸酶水平、肿瘤标志物、有无贫血、血清白蛋白水平、血小板计数等因素的预后价值。结果全组6、12、24个月生存率分别为58.2%、24.6%、0.7%;中位生存期为7个月。单因素分析显示血乳酸脱氢酶、血清白蛋白、贫血、一般状况评分与广泛期小细胞肺癌生存期相关(P<0.05);性别、年龄、发病时是否体质量减轻、血清碱性磷酸酶水平、血小板计数增高与其生存期无关。多因素分析则显示贫血(RR1.531)、血清白蛋白(RR1.493)、血清乳酸脱氢酶水平(RR1.462)是广泛期小细胞肺癌患者的独立预后因素。结论广泛期小细胞肺癌患者,贫血、血清白蛋白降低、血清乳酸脱氢酶水平增高是其预后不良的主要因素。
Objective To retrospectively review the clinical prognostic factors for extensive-stage small cell lung cancer（SCLC）. Methods From Jan 2000 to Dec 2006, clinical data were collected from 134 patients who had been diagnosed extensive-stage SCLC. Kaplan-Meier and Cox regression were used to analyze the relationship between the survival and clinical prognostic factors of 134 cases of extensive-stage SCLC such as gender,age,Kamofsky Performance Status（ KPS）, body mass loss, lactate dehydrogenase （ LDH ）, alkaline phosphatase （AKP）, tumor markers, anaemia, serum albumin,platelet count and others. Results In the whole group,6,12 and 24 month survival rates were 58.2%, 24.6% and 0.7% respectively with a median time to survival of 7 months. Univariate analysis indicated that serum LDH,albumin,anemia and KPS influenced the survival of extensive-stage SCLC（ P 〈0.05）. While gender, age, AKP, body mass loss and platelet count did not influence the survival in extensive-stage SCLC.. Multivariate analysis suggested that anaemia （RR = 1.531）,the serum albumin （RR = 1. 493） and LDH（RR = 1. 462） were the independent prognostic factors of survival. Conclusion Anaemia, lower serum albumin and higher LDH are poor prognostic factors for patients with extensive-stage SCLC.
出处
《临床荟萃》
CAS
2009年第21期1861-1864,共4页
Clinical Focus
关键词
癌
小细胞
体征和症状
预后
carcinoma, small cell
signs and symptoms
prognosis
