摘要
目的分析实性假乳头状肿瘤(SPT)伴肝转移的临床病理特点,提高对该病的认识。方法对1例肝穿刺标本诊断实性假乳头状肿瘤的临床资料、镜下观察及免疫组化结果进行分析。结果组织学:肿瘤有实性区、囊性区及假乳头区,假乳头区肿瘤细胞围绕血管周围排列,以纤细的纤维血管为轴心形成假乳头结构。肿瘤细胞中等大小,较一致,胞质嗜酸或空泡状,细胞核圆形、卵圆形,可见核沟,有轻度异型性。免疫组化:α1-AT、α1-ACT、CD56、Syn、CD10β-catenin和cyclin D1(+),hepatocyte和E-cadherin(-)。结论肝穿刺标本可以诊断少见的转移性SPT,免疫组化检测对诊断具有重要意义。
Objective To study clinicopathologic features of liver metastatic solid-pseudopapillary tumor （SPT）. Methods One case of core needle biopsied liver metastatic SPT was assessed with clinical, pathological and immunohistochemical analysis. Results Histologically, the tumor had solid and pseudopapillary architecture with tumor cells of uniformed size showing slight nuclear pleomorphism. Pseudopapillary structure with a fibrovaseular core was quite remarkable. Immunohistochemically, tumor cells were positive for cd-AT, txl-ACT, CD56, Syn, CD10, [3-catenin, eyclinD1, while hepatocyte and E-cadherin were negative. Conclusion With the help of immunohistochemistry, it is possible to make definite diagnosis of rare metastatic SPT on the core needle biopsy of the liver.
出处
《诊断病理学杂志》
CSCD
2010年第4期278-280,共3页
Chinese Journal of Diagnostic Pathology
基金
北京市科技新星计划项目(2005B-44)资助
关键词
实性假乳头状肿瘤
肝转移
粗针穿刺
Solid-pseudopapillary tumor
Liver metastasis
Core needle biopsy
