摘要
目的探讨胰腺实性假乳头状肿瘤(SPTP)的临床特点、病理诊断、治疗及预后。方法回顾性分析15例SPTP的临床资料、病理组织学特点及免疫组化表达,并复习相关文献。结果 15例SPTP中男性1例,女性14例,年龄10～57岁,中位年龄23岁。肿瘤切面均为囊实性,肿瘤直径4.5～13.2 cm;光镜下其主要特征为肿瘤由被覆数层上皮细胞的假乳头和囊腔形成。免疫组化:vimentin、α-AT、CD10、catenin-β和cyclinD1均(+),13例PR(+),1例ER(+),5例p53(+),5例NSE(+),2例CgA(+),1例CKpan(+);E-cadherin和EMA均(-);Ki-67阳性率均<10%。13例获得随访,随访时间为10～92个月,均未见复发或转移。结论 SPTP是一种好发于青年女性的低度恶性胰腺肿瘤,诊断依据其临床特征、病理组织学特点及免疫组化结果。
Objective To explore the clinical characteristics, pathological diagnosis, treatment and prognosis of solid pseudopapillary tumor of pancreas （SPTP）. Method The clinical data, pathological features and immunohistochemieal expression characteristics of 15 patients with SPTP were collected and retrospectively analyzed. Rusults There were 1 male and 14 famales in this group of SPTPs, ranging in age from 10 to 57 years, with average of 23 years. The tumors were solid-cystic, the size of tumors were from 4. 5 - 13.2 cm. Histologiclly, the tumor cells were mieroeystic structures with typical pseudopapillary pattern. Immunohistochemieally, vinmentin, a-AT, CD10, catenin- [3, cyclin D1 were positive in all cases, PR in 13 cases, ER in 1 cases, [53 in 5 cases, NSE in 5 cases, CgA in 2 cases, CK pan in 1 case, while E- cadherin and EMA were negative. Positive rates of Ki-67 were less than 10%. 13 patients were followed up for a period of 10 -92 months, and they were all alive, had no recurrence and metastasis. Conclusion SPTP is a elinieopathologic entity preferentially in young adult female patients, with a few malignant potential. Clinical feature, pathological morphology and immunohistochemistry are very important in the diagnosis and differential diagnosis of SPTP.
出处
《诊断病理学杂志》
CSCD
北大核心
2013年第9期526-530,共5页
Chinese Journal of Diagnostic Pathology
关键词
胰腺肿瘤
实性假乳头状肿瘤
临床病理学
免疫组化
Pancreas neoplasms
Solid pseudopapillary tumor
Clinical pathology
Immunohistochemistry
