摘要
1例17个月男性患儿,因1型糖尿病行自体造血干细胞移植入院。入院后皮下注射非格司亭5.0μg/kg行造血干细胞动员,给予环孢素25mg,2次/d口服,第12天肝功能正常。停用环孢素,改用抗胸腺细胞球蛋白(ATG)静脉滴注。第1天应用ATG8mg,第2天应用12mg,随后血生化检查:ALT1041U/L,AST209.3U/L,ALP296.4U/L,LDH695.1U/L,TBil19.3μmol/L,DBil11.7μmol/L。立即停用ATG,给予保肝治疗,肝功能逐渐好转。20d后行造血干细胞回输,无不适出院。随访半年肝功能正常。
A 17-month-old male child with type 1 diabetes was hospitalised for undergoing autologous hematopoietic stem cell transplantation. After admission,he was given SC filgrastin 5.0 μg/kg for hematopoietic stem cell mobilization followed by cyclosporine 25 mg twice daily,on day 12,his liver function was normal. Cyclosporine was stopped and changed to an IV infusion of antithymocyte globulin 8 mg on first day and 12 mg on second day. Subsequently,biochemical tests revealed the following values：ALT 1 041 U/L,AST 209.3 U/L,ALP 296.4 U/L,LDH 695.1 U/L,TBil 19.3 μmol/L,DBil 11.7 μmol/L. Antithymocyte globulin was withdrawn immediately and liver-protective treatments were given.His liver function improved gradually. Twenty days later,he received hematopoietic stem cell reinfusion and was discharged without discomfort. His liver function was normal at half a year follow-up.
出处
《药物不良反应杂志》
2010年第4期279-279,298,共2页
Adverse Drug Reactions Journal
基金
上海市自然科学基金资助项目(09ZR1440000)
