摘要
1名30岁男性患者,因上呼吸道感染未行皮试而静脉滴注头孢拉定1.0g。0.5h后出现全身皮疹伴瘙痒,经抗过敏治疗后稍缓解。第3天患者出现乏力、食欲不振、恶心,尿色深,皮肤、巩膜黄染。实验室检查:ALT235.4U/L,AST264.1U/L,γ-GT175.5U/L,ALP239U/L,TBil283.7μmol/L,DBil176.2μmol/L,CHE2153U/L,Cr271.2μmol/L。给予保肝、抗炎及对症治疗,40d后患者症状消退,血生化检查恢复正常。
A 30-year-old man with upper respiratory tract infection received IV cefradine 1.0 g without skin test. Half an hour later, he developed generalized skin rash with pruritus. After anti-anaphylaxis therapy, his symptom relieved slightly. On day 3, the patient developed asthenia, anorexia, nausea, dark urine, and yellowing of the skin and sclera. Laboratory test revealed the levels as follows ：ALT235.4U/L,AST264.1U/L,γ-GT175.5U/L,ALP239U/L,TBil283.7μmol/L,DBil176.2μmol/L,CHE2153U/L,Cr271.2μmol/L.He received liver-protective, anti-inflammatory, and symptomatic treatment. Forty days later, his symptoms resolved, and his blood biochemistry values returned to normal limits.
出处
《药物不良反应杂志》
2007年第5期358-359,共2页
Adverse Drug Reactions Journal
关键词
头孢拉定
急性肝衰竭
cefradine
acute hepatic failure
