摘要
研究充血性心力衰竭（ＣＨＦ）患者在不同心功能状态下及治疗前后血浆肾上腺髓质素（ＡＭ）含量，同时分析其与内皮素（ＥＴ）和血管紧张素 Ⅱ（Ａｎｇ Ⅱ）含量之间的关系。用放射免疫法测定了 ５１例 ＣＨＦ患者和 ３０例对照组的血浆 ＡＭ、ＥＴ和 Ａｎｇ Ⅱ含量。结果发现，ＣＨＦ组不同程度的心功能患者血浆 ＡＭ、ＥＴ、Ａｎｇ Ⅱ含量均较对照组明显增高（Ｐ＜０．０１），且血浆 ＡＭ、ＥＴ、Ａｎｇ Ⅱ含量随心功能恶化而升高，随心功能改善而下降，但仍高于对照组（Ｐ＜０．０１）。ＣＨＦ ，患者治疗前后血浆ＡＭ与ＥＴ、Ａｎｇ Ⅱ含量均呈显著正相关。提示血浆ＡＭ升高可能与ＥＴ和Ａｎｇ Ⅱ含量升高有关，可反映心力衰竭严重程度和作为判断疗效的一项指标。
The changes of plasma adrenomedullin(AM),endotherlin(ET)and angiotensinⅡ(AngⅡ)levels in 51 patients withcongestive heart failure(CHF) before and after treatment were observed. Results showed that plasma AM concentrationswere significantly(P< 0 .01 )hgiher in patients with CHF than those in control subjects. The increase of plasma AM, ETand Ang Ⅱ were paralleled with the severity of CHF. The plasma levels of AM,ET and Ang Ⅱ in patients with CHF de-creased significantly(P < 0. 01 )after treatment compared with those before treatment, but they were still higher than thosein the control subjects(p< 0 .01 ). There was a signficant positive correlation between the plasma levels of AM and ETand Ang Ⅱ before and after treatment. There results suggested that AM might play a certain role in the athophysiology o f CHF. The plasma AM levels in patients with CHF may serve as an index of the severity of CHF and the judgement of therapeutic effects in CHF.
出处
《天津医药》
CAS
1999年第4期195-197,共3页
Tianjin Medical Journal
关键词
心力衰竭
充血性
肾上腺髓质ET
AngⅡ
heart failure,congestive adrenal medulla endothelins renin angiotensin system
