摘要
目的通过测定血清胃蛋白酶原(PG)Ⅰ、PGⅡ水平及其比值变化,探索血清胃蛋白酶原与胃部病变的关系。方法本研究采用观察性病例-对照研究,共834例受检者纳入研究。在做血清试验前,入选者诊断都经活检组织病理学检查证实,并根据病理结果将受检者分为糜烂性胃炎组106例、萎缩性胃炎组208例、胃溃疡组102例、十二指肠球部溃疡组108例、胃癌组106例,正常组204例,每1例均用酶联免疫吸附试验(ELISA)定量测定空腹血清PGⅠ和PGⅡ。结果 PGⅠ和PGR(PGⅠ/PGⅡ)水平在糜烂性胃炎组(140.71±31.51μg/L,14.06±5.01)、十二指肠溃疡组(145.43±34.15μg/L,15.24±4.11)和胃溃疡组(141.63±33.26μg/L,14.71±1.91)显著增高,在萎缩性胃炎组(88.53±17.95μg/L,7.26±2.51)明显低于正常组(124.89±33.26μg/L,11.19±4.79),在胃癌组(49.76±19.52μg/L,3.76±1.21)明显低于正常组和萎缩性胃炎组(均P<0.05)。结论 PGⅠ、PGR水平显著低下可作为萎缩性胃炎和胃癌筛查的有效手段,有助于提高胃癌早诊率。
Objective To explore the relationship of serum pepsinogen and gastric lesions through detection of the serum pepsinogen I and pepsinogen II levels. Methods Observational case-control study was adopted and 834 patients were selected in this study.The patients＇diagnosis was confirmed by pathological examination of biopsy before the serum tests.The patients were divided into 6 groups：106 cases with erosive gastritis,208 cases with atrophic gastritis,102 cases with gastric ulcer,108 cases with duodenal ulcer,106 cases with gastric cancer and 204 cases with normal control.Every patient＇s pepsinogen I and pepsinogen II were tested by ELISA. Results The serum pepsinogen I and PGR（PGⅠ/PGⅡ） level were increased significantly in erosive gastritis group（140.71±31.51μg/L,14.06±5.01）,duodenal ulcer group（145.43±34. 15μg/L,15.24±4.11） and gastric ulcer group（141.63±33.26μg/L,14.71±1.91）,and were decreased significantly in atrophic gastritis group（88. 53±17. 95μg/L,7. 26±2. 51） than normal control group（124.89±33.26μg/L,11.19±4.79）.And its serum level in gastric cancer group（49.76±19.52μg/L,2.76±1.21） was lower significantly than normal control group and atrophic gastritis group （P0.05）.Conclusions The decreased serum pepsinogen I and PGR levels were used as an effective means of screening atrophic gastritis and gastric cancer which may help to improve the diagnostic rate of early gastric cancer.
出处
《齐齐哈尔医学院学报》
2010年第15期2353-2355,共3页
Journal of Qiqihar Medical University
基金
陕西省科技厅科研基金资助
编号:2007k09-03-(4)
关键词
胃疾病
胃癌
胃蛋白酶原
Stomach disease Gastric cancer Pepsinogen
