摘要
选择具有抗菌、抗氧化或抗炎镇痛的药物———水杨酸（ＨＬⅠ）、阿斯匹林（ＨＬⅡ）与具有抗癌活性的二氯二茂钛（Ｃｐ２ＴｉＣｌ２）在非水介质中反应，得到两种具有潜在药理活性的茂钛配合物：Ｃｐ２Ｔｉ（ＬⅠ）２，Ｃｐ２Ｔｉ（ＬⅡ）２．经过元素分析、摩尔电导、核磁共振氢谱与碳谱、红外及紫外光谱等测试，表明水杨酸。
In this paper, two Dicyclopentadienyl compounds of Titanium(IV) Cp 2Ti(L Ⅰ) 2 and Cp 2Ti(L Ⅱ) 2 are synthesized in nonaqueous medium by Titanocene Dichloride(Cp 2TiCl 2) with antitumor activity and Salicylic acid (HL Ⅰ) or Aspirin (HL Ⅱ) which have antimicrobe or antiphlohgist activity. All the complexes are characterized by elementary analysis, 1 H NMR, 13 C NMR,IR,UV spectra, which prove the ligands coordenate to Titanium (IV) ion via carboxyl O with losing a HCl molecule in the monodentate mode.
出处
《浙江大学学报（理学版）》
CAS
CSCD
1999年第2期56-60,共5页
Journal of Zhejiang University（Science Edition）
基金
国家自然科学基金
