摘要
通过对ＨＤＶ 感染肝组织中ＨＤＡｇ 表达和细胞免疫状态的观察发现，ＨＤＡｇ 表达可在一定程度上直接引起肝细胞破坏，同时其表达数目与肝组织中炎症有关，特别是与汇管区中ＣＤ３ ＋ 细胞浸润（ｒ＝ ０－５２１） 和坏死区中ＣＤ８＋ 细胞浸润（ｒ＝ ０－４９５） 有较好相关性。提示ＨＤＶ 的直接细胞毒作用并非是引起肝细胞损伤的唯一因素，细胞免疫特别是ＣＤ８ ＋
The role of HDAg direct cytotoxicity and cellular im munity that HDVinitiated in the livercells damages wereexploredin thisstudy-It was fond that HDAg expressing cells numbers related to hepatic inflam mation especially to CD3 + Tlymphocytes in filtrated in the interlobular areas(r = 0-521)and CD8 + Tlymphocytesin filtrated in the necrotic areas (r= 0-495) ofthe liver-The results suggested that cellularim munity especially CD8+ Tlymphocytes mediated cytotoxity play andimportant rolein theliver cellsinjury-The HDVitself cytotoxity to liver cells damages may be an important in some degree butratherthan the only factor oflivercellsinjury-
出处
《临床肝胆病杂志》
CAS
北大核心
1999年第2期113-115,共3页
Journal of Clinical Hepatology
基金
山东省卫生厅青年科学基金
关键词
丁型肝炎
发病机理
细胞免疫
Delta agent Pathogenesis Cellularim munity Liver cell damage Heptatis Dvirus RNAHepatitis Dvirusantigen
