摘要
目的对喉非霍奇金淋巴瘤（ＬＮＨＬ）这一罕见病变临床病理学特点进行观察，并对其病理诊断、起源组织及与ＥＢＶ感染的关系作一初步探讨。方法复习１８ａ间９例喉ＮＨＬ病理存档资料及临床资料，用免疫组化方法进行病理分型及观察。结果９例均表现为渐进性声嘶伴憋气，６例以呼吸困难急症入院。组织学上多形Ｔ细胞淋巴瘤５例，Ｂ细胞淋巴瘤４例，其中淋巴浆细胞样型和小细胞性各２例。２例Ｂ淋巴瘤作ＥＢＶ免疫组化染色，结果均为阳性。９例中５例确认为喉原发淋巴瘤，２例为上呼吸道多灶病变。结论ＬＮＨＬ中高度恶性的多形Ｔ淋巴瘤超过半数，区分ＬＮＨＬ免疫亚型并探讨其播散方式及与ＥＢＶ感染的关系很有必要。
Objective To analyse the pathomorphology and clinic behavior of laryngeal non Hodgkin′s lymphoma(LNHL) and to study their histological subtype、diagnosis and differentiated diagnosis、 histogenetic tissue and relationship between infection of EBV and LNHL.Methods Pathological and immunohistochemical methods were utilized to analyse 9 cases of LNHL which were localized in laryngeal region during the past 18 years. Results All patients presented with gradually dysphonia and dyspnea, 6 of them were admitted as emergency treatment. Histologically,5 of 9 cases were polymorphoral(peripheral) T cell lymphoma,in the rest 4 of B cell lymphoma, 2 were lymphoplasmacytoid and the other 2 were small cell type.The only 2 of B cell LNHL(1 subtype each one) for EBV antibody with immunohistochemical stain showed positive.5 of 9 cases, 5 were identified primary laryngeal lesion, in which two were associated with regional lymphadenopathy, one of them showed infiltration of bone marrow by lymphomatic cells.Two of the other four lesions were multi focus in the upper aerodigestive tract. Conclusion It's important to differentiate T and B subtype of LNHL and to study further the mode of dissemination of LNHL, and relationship between EBV infection and histogenesis of LNHL.
出处
《白血病》
1999年第2期78-81,共4页
