摘要
目的 探讨异丙酚对颅脑损伤患者开颅手术期间血浆内皮素（ＥＴ）和降钙素基因相关肽（ＣＧＲＰ）含量的影响。方法 急性颅脑损伤（ＡＣＩ）患者４０ 例，随机分为观察组（异丙酚组，ｎ＝ ２０，Ａ组）和对照组（γ羟基丁酸钠组，ｎ＝ ２０，Ｂ组）。以放射免疫分析方法测定４０ 例ＡＣＩ患者麻醉前后血浆ＥＴ、ＣＧＲＰ含量，并以４０例健康献血者为术前对照。结果 ＡＣＩ患者术前ＥＴ及ＥＴ／ＣＧＲＰ明显高于正常对照组（Ｐ＜ ００１）。麻醉后２ 小时，Ａ组ＥＴ较麻醉前显著性降低（Ｐ＜ ００１）而Ｂ组ＥＴ较麻醉前持续显著性升高（Ｐ＜ ００１）；麻醉后４ 小时，Ａ 组ＥＴ，ＥＴ／ＣＧＲＰ较麻醉前更进一步降低（Ｐ＜ ００１），而ＣＧＲＰ较麻醉前有显著性升高且明显高于正常对照组。而Ｂ组ＥＴ较麻醉前仍有显著性升高（Ｐ＜００１），组间比较有显著性差异（Ｐ＜ ００１）。结论 血浆ＥＴ含量变化与颅脑损伤后脑组织继发性损害病生机制密切相关。临床麻醉剂量的异丙酚对ＥＴ有明显的拮抗效应。
Objective To study the effect of propofol on the plasma contents of endothelin (ET) and calcitonin gene related peptide (CGRP) in the patients with acute cerebral injury (ACI) during neurosurgery Methods Forty patients with ACI were divided randomly into two groups The patients were administered intravenously with propofol (propofol group,6 9mg·kg -1 ·h -1 ) or γ OH 60 mg·kg -1 (control group) respectively Plasma ET and CGRP contents were determined before anesthesia, 2 and 4 hours following anesthesia by radioimmunoassay.Results ET level and ET/CGRP were significantly increased before anesthesia in patients with ACI compared to normal value (P<0 01) Two hours after propofol administration ET level significantly decreased in patients with ACI than before anesthsia,four hours following anesthesia,ET and ET/CGRP decreased more than before anesthesia,meanwhile,plasma CGRP level was markedly increased (P<0 01) In control group ET was significantly increased 2 and 4 hours during anesthesia than before anesthesia (P<0 01) Conclusion Therapeutic dosese of propofol may play a role in brain protection
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1999年第4期203-205,共3页
Chinese Journal of Anesthesiology
基金
海南省自然科学基金
