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FGFR2基因SNP位点rs11200014多态性与中国女性乳腺癌易感性的关系 被引量：1

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摘要 目的:研究成纤维细胞生长因子受体2(FGFR2)基因单核苷酸多态性(SNP)位点rs11200014多态性与中国女性乳腺癌易感性的关系。方法:抽取321例乳腺癌患者和330例健康对照组外周血,分离淋巴细胞,抽提基因组DNA,采用聚合酶链-连接酶检测反应检测FGFR2基因SNP位点rs11200014多态性,比较基因型分布和乳腺癌发病风险及临床病理特征的关系。计算危险度比值比及95%CI,应用非条件Logistic回归进行分析计算。结果:FGFR2基因SNP位点rs11200014多态性与中国女性乳腺癌发生风险无明显关系,与淋巴结转移、雌激素受体及孕激素受体状态无明显相关。在年龄大于50岁的女性中,rs11200014CT基因型降低了患乳腺癌的风险。结论:FGFR2基因SNP位点rs11200014多态性与中国女性乳腺癌易感性之间无明显相关性。
作者 周希科 李莉华 黄朝晖 刘志辉 宋明旭
机构地区 苏州大学附属第四人民医院肿瘤研究所
出处 《实用医学杂志》 CAS 北大核心 2010年第17期3137-3139,共3页 The Journal of Practical Medicine
基金 无锡市科技局科技发展计划资助项目(编号:CAE00801-08) 无锡市科技局社会发展计划资助项目(编号:CSE00708)
关键词 乳腺肿瘤 乳腺癌易感性 成纤维细胞生长因子受体2 基因型分布
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献8

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同被引文献15

  • 1Easton DF,Pooley KA,Dunning AM,et al.Genome-wide association study identifies novel breast cancer susceptibility loci.Nature,2007,447:1087-1093.
  • 2Hunter DJ,Kraft P,Jacobs KB,et al.A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer.Nat Genet,2007,39:870-874.
  • 3Raskin L,Pinchev M,Arad C,et al.FGFR2 is a breast cancer susceptibility gene in Jewish and Arab Israeli populations.Cancer Epidemiol Biomarkers Prey,2008,17:1060-1065.
  • 4Stacey SN,Manolescu A,Sulem P,et al.Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer.Nat Genet,2007,39:865-869.
  • 5Li L,Zhou X,Huang Z,et al.TNRC9/LOC643714 polymorphisms are not associated with breast cancer risk in Chinese women.Eur J Cancer Prey,2009,18:285-290.
  • 6Tomlinson I,Webb E,Carvajal-Carmona L,et al.A genomewide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.Nat Genet,2007,39:984-988.
  • 7Zanke BW,Greenwood CM,Rangrej J,et al.Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.Nat Genet,2007,39:989-994.
  • 8Haiman CA,Le Marchand L,Yamamato J,et al.A common genetic risk factor for colorectal and prostate cancer.Nat Genet,2007,39:954 -956.
  • 9Amundadottir LT,Sulem P,Gudmundsson J,et al.A common variant associated with prostate cancer in European and African populations.Nat Genet,2006,38:652-658.
  • 10Gudmundsson J,Sulem P,Manolescu A,et al.Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.Nat Genet,2007,39:631-637.

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实用医学杂志
2010年 第17期

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