摘要
目的：比较氨氯地平与硝苯地平治疗老年单纯性收缩期高血压病的疗效及安全性。方法：氨氯地平组３４例（男性２０例，女性１４例，年龄６８．８ａ±ｓ１．２ａ）用氨氯地平５～１０ｍｇ，ｐｏ，ｑｄ×８ｗｋ；硝苯地平组３４例（男性１８例，女性１６例，年龄６７．８ａ±１．３ａ）用硝苯地平１０～２０ｍｇ，ｐｏ，ｔｉｄ×８ｗｋ。结果：氨氯地平降压总有效率９４％，硝苯地平９１％，２组疗效差别无显著意义（Ｐ＞０．０５），不良反应发生率氨氯地平组１２％，硝苯地平组２４％，差别有非常显著意义（Ｐ＜０．０１）。结论：氨氯地平治疗老年收缩期高血压病疗效好，在安全性方面优于硝苯地平。
AIM: To compare the effects of amlodipine and nifedipine in treating aged with simple systolic hypertension. METHODS: Thirty_four patients (M 20, F 14; age 68.8 a±s 1.2 a) received amlodipine 5_10 mg, po, qd for 8 wk. Another 34 patients (M 18, F 16; age 67.8 a±1.3 a) received nifedipine 10_20 mg, po, tid for 8 wk. RESULTS: The clinical total effective rate of amlodipine group was 94%, without significant difference with that of the nifedipine group (91%) (P>0.05). Adverse reactions of amlodipine group were fewer than those of nifedipine group (12% vs 24%, P<0.01). CONCLUSION: Amlodipine is a safe and effective drug. It is superior to nifedipine in treating aged with systolic hypertension.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
1999年第2期70-72,共3页
Chinese Journal of New Drugs and Clinical Remedies
