摘要
目的分析冠心病患者心肌梗死时血浆同型半胱氨酸(Hcy)、血管性血友病因子(vWF)、凝血因子和抗凝血因子的变化,探讨冠心病患者实验室监测指标在降低冠心病患者心肌梗死风险的意义。方法检测并回顾分析66例心肌梗死患者的血浆Hcy、vWF、凝血因子及抗凝血因子的变化,并与对照组50例患者进行比较。结果心肌梗死患者组血浆Hcy、vWF、纤维蛋白原(FIB)、凝血酶原活性(PA)、凝血酶活性(TA)水平均显著高于对照组,差异有统计学意义(P<0.001);活化部分凝血活酶时间(APTT)和凝血酶时间(TT)较对照组明显缩短,差异有统计学意义(P<0.001),而两组的凝血酶原时间(PT)差异无统计学意义(P>0.05);抗凝血酶Ⅲ活性(AT-Ⅲ:A)和血浆蛋白C活性(PC:A)则显著低于对照组,差异有统计学意义(P<0.001)。结论血浆Hcy、血管内皮损伤、凝血和抗凝血系统功能失调等改变是心肌梗死发生的重要危险因素,可将Hcy、vWF、FIB等作为冠心病患者定期的实验室监测指标,起到积极预防心肌梗死发生的作用。
Objective To analyze the change of plasma homocysteine（Hcy）,vascular hemophilia factor（vWF）,blood coagulation factor and anticoagulation factor and to study the significance of laboratory monitoring indexes on reducing the risk of acute myocardial infarction（AMI） in the patients with coronary heart disease（CHD）.Methods To detect and retrospectively analyze the change of plasma Hcy,vWF,coagulation factor and anti coagulation factor in 66 cases of AMI and to conduct the comparison with 50 cases of control group.Results In AMI group,plasma levels of Hcy,vWF,fibrinogen（FIB）,prothrombin activity（PA） and thrombase activity（TA） were obviously higher than those in the control group with statistic difference（P〈0.001）.The activated partial thromboplastin time（APTT） and the thrombin time（TT） were obviously reduced compared with the control group,the difference had statistic significance（P〈0.001）,but the difference of the prothrombin time（PT） between the two groups had no statistic significance（P〈0.05）;the antithrombin Ⅲ activity（AT Ⅲ：A） and the plasma protein C activity（PC：A） were obviously lower than those in the control group,the difference had statistic significance（P〈0.001）.Conclusion Plasma homocysteine（Hcy）,vascular endothelial damage,disfunction of coagulation and anticoagulation systems are the important risk factors of AMI.Hcy,vWF,FIB,etc.,may be taken as the regular laboratory monitoring indexes for CHD patients,which play the role on positively preventing occurrence of AMI.
出处
《检验医学与临床》
CAS
2010年第16期1693-1694,共2页
Laboratory Medicine and Clinic
关键词
冠心病
心肌梗死
实验室监测
coronary heart disease
acute myocardial infarction
laboratory monitoring
