摘要
目的观察老年无症状性脑梗死（silent cerebral infarceion，SCI）患者血管内皮损伤及凝血、抗凝血指标的变化。方法选择SCI患者（SCI组）47例和健康体检者（对照组）47例，抽取空腹静脉血，分别检测血管性血友病因子（vWF）、凝血酶原时阿（PT）、活化部分凝血活酶时间（APTT）、凝血时间（TT）、纤维蛋白原（Fib）含量、凝血酶原活性（PA）、凝血酶活性（TA）、抗凝血酶Ⅲ活性（AT-Ⅲ：A）和血浆蛋白C活性（PC：A）。结果SCI组vWF水平显著高于对照组[（196．7±25．3）％vs（143．6±21．1）％，P〈0．01]，SCI组APTT和TT较对照组明显缩短[（25．7±8．3）s vs（37．8±9．5）s，（9．2±1．8）s vs（15．3±2．8）s，P〈0．01]，SCI组PT与对照组比较差异无统计学意义（P〉0．05），SCI组Fib含量明显高于对照组[（4．6±4.2．3）g／L vs （2．6±1．3）g／L,P〈0．01]，PA和TA明显高于对照组，而AT-Ⅲ：A和PC：A则明显低于对照组（P〈0．01）。结论血管内皮桶伤及凝血、抗凝血系统功能失调导致的高凝状态是SCI发生的危险因素。
Objective To observe endothelial cell damage and the changes of blood coagulatign and anticoagulation indexes in the elderly patients with silent aerebral infarction（SCI）. Methods The level of yon Willebrand factor （vWF） was measured by enzyme linked immunosorbent assay （ELISA） in 47 patients with SCI and 47 healthy persons of control group over 60 years old. The prothrombin time（PT）, activated partial thromboplastin time （APTT）, thrombin time （TT）, fibrinogen（Fib）, prothrombin activity （PA）, thrombin activity （TA）, antithrombin m （AT- Ⅲ ） activity and protein C（PC） activity were also measured in both groups. Results The level of vWF was significantly higher in patients with SCI than in the control group[（ 196. 7±25. 3）% vs （143.6±21.1） %, P 〈0.01]. APTT and TT were markedly shortened in SCI group than in the control group [-（25.7±8.3） s vs （37.8±9.5） s,（9.2±1.8） s vs （15.3±2.8） s, P〈0.01,respectively],but PT was not significantly different between the two groups （ P 〉0.05）. The concentration of Fib was significantly higher in SCI group than in the control group [-（4.6±2.3） g/L vs （2. 6 ± 1.3） g/L, P 〈 0. 01]. PA and TA were significantly increased, but the activities of AT-Ⅲ and PC were markedly decreased in SCI group as compared with those in the control group （P 〈0.01）. Conclusion Endothelial cell damage and hypercoagulation state caused by coagulation and anticoagulation dysfunction are risk factors for SCI.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2008年第12期911-913,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
河南省医学科技攻关计划项目（2006）
郑州市科技攻关计划项目（064SGYS33216-2）
关键词
脑梗塞
内皮
血管
血液凝固
纤维蛋白
抗凝血酶Ⅲ
brain infarction
endothelium, vascular
blood coagulation
fibrin
antithrombin Ⅲ
