摘要
目的探讨结膜下植入羊膜联合地塞米松等药物点眼对中度兔眼碱烧伤的治疗作用。方法 48只新西兰大白兔48只眼制作碱烧伤模型,随机分为2组。A组局部给氧氟沙星眼液,地塞米松眼液,10%枸橼酸钠,结膜下注射维生素C+庆大霉素。B组除接受与A组相同的治疗外,在结膜下植入羊膜。比较两组的疗效。结果烧伤后第1天球结膜充血程度B组明显比A组轻(P<0.05)。烧伤后第30天角膜透明度两组无明显差异(P>0.05),但B组眼部疤痕明显好于A组(P<0.05),角膜新生血管及透明度无明显差异(P>0.05),光镜下A组纤维结缔组织增生,B组结膜组织的上皮层和固有层清晰可见,未见纤维组织增生。结论结膜下植入羊膜有利于碱烧伤后结膜的修复,减轻结膜的纤维增生,减少睑球粘连的发生。
Objective To explore the treatment effect of subconjunctival amnion implantation on moderate alkali burn of rabbit eyes. Methods The models of corneal alkali burn were established in 48 New Zealand rabbit eyes and randomly divided into 2 groups. Group A was treated with Ocuflox, aqueous dexamethasone eye drop solution, citric acid, vitamin C and gentamicin. Group B received amnion implantation under the conjunctiva besides the same treatment as group A. Therapeutic effects were compared between the two groups. Results The therapeutic effect was superior in group B to group A. On the 1st day, the conjunctival congestion was slighter in group B than in group A （P0.05）. On the 30th day, the corneal clarity showed no obvious difference between the two groups （P0.05）, but the conjunctival scar formation was slighter in group B than in group A （P0.05）. The optical microscopy showed the fiber connective tissue hyperplasia in group A, and the epithelial layer and lamina propria were clear and no fiber hyperplasia was observed in group B.Conclusion Subconjunctival amnion implantation helps to repair the conjunctiva after alkali burn, and reduce the fiber hyperplasia and occurrence of symblepharon.
出处
《华南国防医学杂志》
CAS
2010年第4期250-253,共4页
Military Medical Journal of South China
关键词
碱烧伤
羊膜
睑球粘连
结膜
Alkali burn
Amnion
Symblepharon
Conjunctiva
