摘要
目的探讨婴幼儿病毒性腹泻的流行现状与流行特点。方法采集2008-08-01—2009-07-31广州市儿童医院就诊的急性腹泻患儿粪便标本并记录其病情信息,运用实时荧光定量PCR法对采集的985例患儿粪便标本进行轮状病毒(HRV)、肠道腺病毒(EADV)、诺如病毒(NORV),扎如病毒(SPAV)、星状病毒(ASTV)检测。结果腹泻病毒的年检出率为45.9%,混合感染率为22.8%,未发现GI组NORV株,单月中11月检出率最高76.3%,HRV、NORV、EADV、ASTV、SPAV的年检出率分别是28.0%、13.7%、8.8%、4.9%、1.0%,95%的阳性标本来自2岁以下婴幼儿,水样便、呕吐、发热的发生率为88.9%、75.2%与68.4%。结论病毒性腹泻是本地季节性婴幼儿急性腹泻常见原因,10～12月是发病高峰,2岁以下婴幼儿是主要的流行人群,HRV是最重要的病原体,水样便、发热、呕吐是婴幼儿病毒性腹泻的三联症。混合感染较常见但其症状较单一感染可能并未加重。
Objective To analyze the prevalence characteristic of viral diarrhea in Guangzhou. Methods Totally 985 specimens and condition information were collected from children with acute diarrhea in Guangzhou Children＇ s Hospital from August 2008 to July 2009, then real-time fluorescence quantitative PCR was employed to detect HRV, NORV, EAdV, ASTV and SPAV. Results Among the 985 specimens 452 specimens were positive, in which 103 specimens was found with co-infection; the annual rate of HRV, NORV, EAdV, ASTV and SPAV was 28.0%, 13.7 %, 8.8%, 4.9% and 1.0% .About 95% of positive samples were from infants under 2 years of age; the incidence rate of watery, stools, fever and vomit was 88.9%, 68.4% and 75.2%. Conclusion Viral diarrhea is the most common cause in infants and young children with acute diarrhea. HRV is the most important pathogens. October to December is the peak incidence. Infants under 2 years is a major pop groups. Watery stools, fever and vomiting is infantile viral diarrhea triad. Co-infection is common but has little influence on symptoms.
出处
《中国实用儿科杂志》
CSCD
北大核心
2010年第8期618-621,共4页
Chinese Journal of Practical Pediatrics
