摘要
尿毒康是广州中医药大学第二附属医院治疗慢性肾功能衰竭的有效制剂，该方主要由大黄、何首鸟、黄芪、女贞子等药组成，具有益气温阳，健脾益肾，活血泻浊的功效。为了探讨该药对慢性肾功能衰竭大鼠模型脂质代谢的影响，采用5／6肾切除改良法制作大鼠肾衰模型，模型制作后2周，按一般状态、24h尿蛋白定量配对后，随机分成模型对照组、尿毒康高剂量组、尿毒废低剂量组和包醛氧淀粉组，并与正常对照组比较，观察尿毒康对血清甘油三酯、胆固醇和载脂蛋白的影响。结果：模型对照组的血脂明显高于正常组，经过尿毒康治疗后血脂水平明显降低。表明：尿毒康在改善脂质代谢方面有良好的效果。
Niaodukang is an effective formula used in the second affiliated hospithal of Guangzhou Universityof TCM for chronic renal failure, which is composed of Rhizoma Rhei,Radix Polygoni Multiflori,Radix Astragali seu Hedysari and Fructus Ligustri Lucidi with the actions of supplementing qi, warmingYang, strengthening spleen, tonifying kidney, promoting blood circulation and removing turbid pathogenicfactor. To explore the effect of Niaodukang on the lipid metabolism of chronic renal faiure, rat model wasset up with improved technique of 5/6 kidney mass removal. After the accomplishment of the rat model for2 weeks, the models matched with the geneal conditions and 24 hours' proteinuria were randomly allocated to five groups: the model group,two Niaodukang groups with high and low dosages respectively, CoatedAldehyde Oxystarch group and the nounal control group. Serum contents of triglyceride, cholesterol andapoprotein were tested.The results showed that the blood lipid level in the model group was higher than thenormal group,and decreased markedly after the treatment of Niaodukang. It is indicated that Niaodukang exerts a good effect on the blood-lipid metabolism in rat model with chronic renal failure.
出处
《广州中医药大学学报》
CAS
1999年第2期148-150,共3页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省科委重点科技攻关项目
关键词
尿毒康
肾功能衰竭
补益脾肾
中医药疗法
@NIAODUKANG /pharmacology
KIDNEY FAILURE, CHRONIC/TCD therapy
REINFORCING SPLEEN & KIDNEY
ACTIVATING BLOOD
TRIGLYCERIDES/blood
CHOLESTEROL/blood
CARRIER PROTEINS
RATS
