摘要
目的 :制作腺嘌呤致慢性肾功能衰竭大鼠疾病模型。方法 :Wistar大鼠腺嘌呤 2 0 0 mg/kg灌胃 ,1次/d,连续 2 4d。观察大鼠一般状态的改变 ,检测血液 ,生化学指标 ( RBC、HGB、HCT、BUN、Scr、Ca2 + 、P5+ ) ,肾脏病理组织学检查。结果 :模型出现 RBC、HGB、HCT降低 ,BUN、Scr升高 ,低钙高磷 ,慢性肾功能衰竭主要血生化改变。肾脏病理组织学以肾小管损害为主。结论
Objective: To make disease model of chronic renal failure (CRF) in rats by adenine. Methods: We fed the Wistar rats 200 mg/kg adenine per day and kept feeding them with the same dosage for 24 days. We observed the general health conditions and tested hematologic and biochemical indices (RBC, HGB, HCT, BUN, Scr, Ca 2+, P 5+) and changes in histopathology. Results: The disease model had the CRF symptoms of reduced levels of RBC, HGB, HCT, Ca 2+ and increased levels of BUN, Scr and P 5+. In histopathology, the disease model had main damage in renal tubules. Conclusion: The adenine was suitable for making disease model of CRF in rats.
出处
《内蒙古医学院学报》
2004年第4期248-249,253,共3页
Acta Academiae Medicinae Neimongol
