摘要
目的：探讨胃癌组织中雌激素受体（ER）、孕激素受体（PR）和C．erbB－2表达及其临床意义。方法：应用链霉菌亲生物素蛋白过氧化酶法（S－P法），对65例胃癌标本中ER、PR和C-erbB-2进行免疫组化染色。结界：ER、PR阳性表达率分别为52．3％和49．2％。其阳性率与癌细胞分化程度、浸润深度和淋巴结伴有癌转移呈正相关（P＜0．05）。C-erbB-2阳性表达率为23．0％，其阳性率与癌细胞分化程度呈负相关（P＜0．05），与癌浸润深度和淋巴结伴有爆转移呈正相关（P＜0．05）。结论：ER、PR和C－erbB－2阳性表达的胃癌患者预后较差。
Objechve: To approach the clinical significance of the expression of estrogen recep- tor(ER), progestogen receptor(PH)and C-erbB-2 in human gastric cancer. Methods: The ER, PR and C-erbB-2 in 65 gastric cancer samples were stained by stre ptavidin- peroxidase immunohistochemical meth - od. Results: The positive expression rates of ER and PR were 52. 3 % and 49. 2 %, respectively, and the rates were positively correlated with differentiation degree, indltration depth and lymphatic metastasis of the cancer cells(P < 0 .05). The positive expression rate of C-erbB-2 was 23 .o% and it was negatively correlated with differentiation degree of the cancer cells(P < 0 .05), but Positively with ianfiltration depth and lymphatic metastasis of the cancer cells(P < 0.05 ). Concusion: The prognosis of gastric cancer pa- tients with the positive expressions of ER, PR or C-erbB-2 will be poor.
关键词
胃癌
雌激素受体
孕激素受体
免疫组织化学
gastric cancer
estrogen receptor
progestogen receptor
C-erbB-2
immunohistochemistry
