摘要
应用免疫组化ＡＢＣ法，对１００例乳腺癌的表皮生长因子受体（ＥＧＦＲ）、ＥＲ及ＰｇＲ进行了检测。结果显示：ＥＧＦＲ阳性３４例，ＥＲ阳性６ｌ例，ＰｇＲ阳性３０例。其中３项均阳性者５例，ＥＲ与ＥＧＦＲ，ＰｇＲ与ＥＧＦＲ阳性者各８例，结果说明乳腺癌中ＥＧＦＲ阳性率高于良性乳腺肿瘤，差异显著（Ｐ＜０．０１）。ＥＧＦＲ在乳腺癌中的表达与ＥＲ表达呈显著负相关关系（Ｐ＜０．０５）；ＥＲ的表达与患者的绝经状态显著相关（Ｐ＜０．０５）；不同病理组织学类型的乳腺癌ＥＧＦＲ阳性率存在一定差异；而ＥＲ是乳腺癌高分化、预后好的标志，ＥＧＦＲ则相反（Ｐ＜０．０１）。
The ABC immunohistochemical method was performed on 100 cases of human breast cancers to detect receptors (R) of epidermal growth factor (EGF), estrogen (E) and progestogen (Pg). The results showed that there were 34 EGFR-, 61 ER- and 30 PgR - positive cases among all cancers examined. In the EGFR - positive cases, there were 5 ER - and PgR - positive cases, 8 ER - and 8 PgR - positive cases. The results suggested that there be (1) a significant difference (p<0. 01) in EGFR - positive rate between the malignant and benign breast tumors (control group), (2) a significant negative correlation between the expressions of EGFR and ER (p<0. 05)in breast cancer , (3) the ER - positive rate correlated with the patients'status of menopause (p<0. 05), and (4)a certain difference in EGFR - positive rate in different subgroups of human breast cancers. It is concluded that ER is a predictor showing well - differentiated carcinoma with relatively good prognosis, but EGFR, an inverse above predictor.
出处
《诊断病理学杂志》
CSCD
1995年第2期96-98,共3页
Chinese Journal of Diagnostic Pathology
关键词
乳腺癌
表皮生长因子
雌激素
孕激素
受体
Breast cancer
Epidermal growth factor receptor
Estrogen receptor
Progestogen receptor
