摘要
【目的】探讨蛋白质对早产儿早期免疫功能的影响。【方法】根据出生2周内摄入蛋白质量的不同对43例早产儿进行分组,平均摄入蛋白质≥3 g/(kg.d)为高蛋白组,而摄入蛋白质<3 g/(kg.d)为一般蛋白质组。比较两组早产儿3日龄、第二周IgA、IgG、IgM、C3、C4、CD3、CD4、CD8、CD4/CD8、血尿素氮(BUN)、肌酐(SCr)的水平。【结果】出生满2周,高蛋白质组IgM水平较治疗前升高,与一般蛋白质组差异有统计学意义(P<0.05);两组IgG水平较治疗前下降(P<0.01),两组T细胞亚群CD3、CD4、CD4/CD8比值均有明显增高,CD8值下降,治疗前后比较有差异高度有统计学意义(P<0.01);治疗后高蛋白质组与一般蛋白质组CD3、CD4、CD4/CD8水平比较差异有统计学意义(P<0.05);CD8值两组无统计学意义(P>0.05);【结论】提高早产儿早期营养中蛋白质的量[≥3 g/(kg.d)],能改善其免疫功能。
【Objective】 To explore the effect of protein intake on early immunity of the premature infants. 【Methods】 According to different amounts of protein intake during the first 2 weeks,43 premature infants were divided into high protein group and common protein group.The amounts of protein intake in the high protein group were at least 3.0 g/（kg·d） while in the common protein group were less than 3.0 g/（kg·d） during the first 2 weeks.Immunoglobulin（IgA,IgM,IgG）,complement（C3,C4） and T-lymphocyte subsets（CD3,CD4,CD4/CD8）were checked in the third day before treatment and the 2 weeks after treatment.The blood urea nitrogen（BUN）,serum creatinine（SCr） were analyzed at postnatal the third day and 2nd week in two groups. 【Results】 2 weeks later,IgM of high protein group were higher than those before treatment,and had significant difference compared common protein group（P0.05）;IgG in two groups both decreased than those before treatment（P0.01）,T cell subsets CD3,CD4,CD4/CD8 in two groups were markedly improved,CD8 decreased,and had highly significant differences before-and-after treatment（P0.01）;CD3,CD4,CD4/CD8 had significant differences between high protein group and common protein group after treatment（P0.05）;CD8 in both group had no significant difference（P0.05）; 【Conclusion】 Immune function of the premature infants could be improved by increasing the protein intake[≥3 g/（kg·d）]in early stage of their life.
出处
《中国儿童保健杂志》
CAS
2010年第8期686-688,共3页
Chinese Journal of Child Health Care
基金
广东省佛山市科技局科研项目(200808111)
关键词
早产儿
蛋白质
免疫功能
premature infant
protein
immune function
