期刊文献+

新疆维吾尔族原发性高血压与同型半胱氨酸的关系 被引量:1

Relationship between the level of homocysteine and essential hypertention in uyger of Xinjiang
暂未订购
导出
摘要 目的:探讨新疆维吾尔族原发性高血压与同型半胱氨酸(Hcy)的关系。方法:对59例维吾尔族原发性高血压患者和58例正常对照组采用荧光偏振免疫法测定血清Hcy水平。结果:两组间在年龄,性别及吸烟情况上分布均衡,无显著性差异。高血压患者血Hcy水平显著高于对照组[(14.60±6.61)μmol/L∶(10.32±4.47)μmol/L,P<0.05]。结论:Hcy与高血压的发病有关,其水平升高可能参与了高血压的发病机制。 Objective: To investigate the relationship between the level of homocysteine and essential hypertention in uyger of Xinjiang. Methods: All the subjects were divided into 2 groups: observation group (59 case with hypertension) and control group (58 heahhy people), all the subjects were detected the levels of Hcy, free plasma glucose, blood lipid (including cholesterol, triglyeeride, high density lipoprotein and low density lipoprotein), then every index of two groups were compared. Results: The mean level of Hcy in observation group was significant higher than that in the control group [ (14.60±6.61) μmol/L vs. (10.32±4. 47) μmol/L, P〈0. 05]. Conclusion: The elevated level of Hcy probably is one of risk factor of hypertension.
出处 《心血管康复医学杂志》 CAS 2010年第4期403-405,共3页 Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词 高血压 半胱氨酸 维吾尔族 Hypertension Cysteine Uygur nationality
  • 相关文献

参考文献11

  • 1Boers GH.Hyperhomocysteinemia as a risk factor for arterial and venous disease.A review of evidence and relevance[J].Thromb Haemost,2001,78:520-522.
  • 2李群.全国高同型半胱氨酸血症与疾病学术研讨会纪要[J].中华医学杂志,1999,79(6):406-408. 被引量:81
  • 3Tyrrell KS,Bostom A,Selhub J,et al.High homocysteine levels are independently related to isolated systolic hypertension in older adults[J].Circulation,2001,96:1745-1749.
  • 4Mendis S,Athanda SB,Naser M,et al.Association between hyperhomocysteinaemia and hypetension in Sri lanka[J].J Int Med Res,2001,27(1):38-44.
  • 5Rolland PH,Friggi A,Barlatier A,et al.Hyperhomocysteinemia-induced vascular damage in the minipig[J].Circulation,1995,91:1161-1174.
  • 6Lim U,Cassano PA.Homocysteine and blood pressure in the third national health and nutrition examination survey,1998-1994[J].Am J Epidemiol,2002,156(12):1105.
  • 7Pierre H,Rollll AF,Andre B,et al.Hyperhomocysteinemia induced vascular damage in the minipig[J].Circulation,2001,91:1161-1173.
  • 8Tatchum-Talom R,Niederhoffer N,Amin F,et al.Aortic stiffness and left ventricular mass in a rat model of isolated systolic hypertension[J].Hypertension,2001,26(6 Pt 1):963-970.
  • 9Tawakol A,Oml T,Gerhard M,et al.Hyperhomocysteinemia isassociated with in inpaired endothelium-dependent vasodialation in human[J].Circulation,2001,95:1119-1121.
  • 10Yamamoto M,Hara H,Adachi T.Effect of homocysteine on the binding of extracellular superoxide dismutase to the endothelial cell surface[J].FEBS Lett,2000,486:159-162.

二级参考文献8

  • 1唐朝枢,齐永芬.血管活性肽与微循环[J].微循环学杂志,2004,14(3):1-4. 被引量:7
  • 2李俊芳,傅增泮,胡建.原发性高血压患者胰岛素抵抗与血浆肾上腺髓质素的关系[J].心血管康复医学杂志,2005,14(3):218-219. 被引量:5
  • 3Feikelsteine JD. The metabolism of homocysteine: pathways and regulation [J]. EurJ Pediatr, 1998, 157 (Suppl 2) :S40.
  • 4Tsai JC,Perrella MA, Yoshizumi M, et al. Promotion of vascular smooth muscle cell growth by homocysteine:a link to atherosclerosis[J]. Proc Natl Acad Aci USA, 1999 ;91 (14) :6369.
  • 5Fryer RH, Wilson BD, Gubler DB, et al. Homocysteine, a risk faetor for premature vascular disease and thrombosis, induces tissue factor activity endothelial cells [J]. Arterioscler and Thromb, 2000, 13 (9), 1327.
  • 6Kohno M, Yokokawa K, Yasunari K, et al. Induction by lysophosphosphatidylcholine, a major phospholipid component of atherogenic lipoproteins, of human coronary artery smooth musclecell migration [J]. Circulation, 1998, 98 (4): 353-359.
  • 7Kohno M, Yokokawa K, Kano H, et al. Adrenomedullin is a potent inhibator of angiotensin Ⅱ-induced migration of human coronary artery smooth muscle cells [J]. Hypertension, 1997, 29 (6): 1309-1313.
  • 8Suan C, Louis M, Fouseca V. Hyperhomocysteinemia:An emerging and important risk factor for thromboembolic and eardiovascular disease [J]. Clinchem, 1996, 106: 709-722.

共引文献104

同被引文献16

  • 1Baszczuk A, Kopczyski Z. Hyperhomocysteinemia in patients with cardiovascular disease [ J ]. Postepy Hig Med Dosw ( On- line). 2014,68 (2) :579 - 589.
  • 2Mazza A, Cuppini S, Schiavon L, et al. Hyperhomocysteinemia is an independent predictor of sub-clinical carotid vascular dam- age in subjects with grade-1 hypertension [ J ]. Endocrine,2014, 46(2) :340 -346.
  • 3Zheng H,Li Y, Xie N, et al. Echocardiographic assessment of hypertensive patients with or without hyperhomocysteinemia [ J ]. Clin Exp Hypertens. 2014 ;36 ( 3 ) : 181 - 6.
  • 4Gralmm 1M,Daly LE, Refsum HM, et al. Plasma homocysteine a risk factor for vascular disease, The European Conceaed Action Proiect[ J]. JAMA.1997.277(22) :1775 - 1781.
  • 5Larry B, Goldstein, Chery 1D, et al. Guidelines for the primary prevention of stroke : a guideline for healthcare professionals from the American Heart Association/American Stroke Associa- tion [J]. Stroke ,2011,42 (2) :571 - 584.
  • 6Lim U, Cassano PA. Homocysteine and blood pressure in the Third National Health and Nutrition Examination Survery [J]. Am J Enidemiol 2012.156(12) :110 -115.
  • 7Wald DS,Law M, Morris JK. Homocysteine and cardiovascular disease: evidenceon causality from a meta-analysis [ J ]. BMJ, 2002,325 (7374) :1202 - 1209.
  • 8傅世英,李为民,赵玉娟,董礼航,赵景波,王付曼.哈尔滨市高血压患病率及其相关因素[J].中华医学杂志,2008,88(42):2966-2970. 被引量:17
  • 9种冠峰,张文明,高杰,相有章,王秀红.山东省山区居民高血压患病及危险因素分析[J].中国公共卫生,2010,26(11):1345-1347. 被引量:11
  • 10张岩,霍勇.伴同型半胱氨酸升高的高血压——“H型”高血压[J].心血管病学进展,2011,32(1):3-6. 被引量:240

引证文献1

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部