摘要
目的探讨血清肝细胞生长因子(HGF)水平及其受体c-Met在宫颈癌中的表达。方法采用酶联免疫吸附法(ELLSA)及免疫组化法测定15例正常宫颈、例CINⅠ-Ⅱ及15例CINⅢ、例宫颈浸润癌患者血1271清HGF的含量及其组织c-Met受体的表达。结果宫颈浸润癌血清HGF平均浓度为458pg/ml,显著高于正常宫颈175pg/ml、CINⅠ-Ⅱ168pg/ml、CINⅢ245pg/ml(P均<0.05);宫颈浸润癌组织c-Met受体阳性率为52.1%显著高于正常宫颈及CIN(P<0.05),宫颈癌患者血清HGF水平与其组织中c-Met表达阳性率成正相关。结论宫颈癌血清HGF水平及其组织c-Met阳性表达增高可能是宫颈癌发生发展及侵袭的重要因素,HGF/c-Met联合检测可能成为宫颈癌诊断的指标。
Objective To investigate the serum content of HGF and the expression of c-Met in cervical cancer.Methods Levels of the serum HGF was determined by Elsa and expression of c-Met was determined by immunohistochemistry in 15 cases with normal cervix,12 cases CINⅠand CINⅡ,15 cases CIN Ⅲ and 71 cases cervical cancer.Results The concentration of serum HGF in cervical cancer which was 458 pg/ml was significantly higher than normal cervix and CIN （ P0.05） .Expression of c-Met in cervical cancer which was 52.1% was higher than that in normal cervix and CIN （ P0.05） .The relation of the levels of the serum HGF and the expression of c-Met in cervical cancer is positive （ P0.05） .Conclusions HGF/c-Met may become a diagnosis target of cervical cancer.The higher serum content of HGF and positive expression of c-Met may play important role in infiltrating and the transfer process of cervical cancer.
出处
《宁夏医学杂志》
CAS
2010年第8期677-679,F0002,共4页
Ningxia Medical Journal
基金
宁夏自然科学基金资助项目(NZ08104)
