摘要
目的探讨正常老年人与阿尔茨海默病(Alzheimer’s disease,AD)患者的尿甲醛浓度。方法随机选取年龄≥65岁的正常老年人(正常组)和确诊为AD患者-(AD组)各30例,对2组患者的尿甲醛浓度进行测定分析。结果 AD组患者尿甲醛浓度(0.26±0.22)mmol/L,显著高于正常组(0.04±0.02)mmol/L,差异有统计学意义(t=-5.269,P<0.01)。结论机体内甲醛浓度超标可能是老年人发生AD的一个原因。
Objective To compare the urine formaldehyde concentration of normal elderly and Alzheimer’s disease elderly.Methods Thirty normal elderly as normal group and 30 Alzheimer’s disease elderly as patient group were selected at random.Two groups’ urine formaldehyde concentrations were measured and analyzed.Results The urine formaldehyde concentrations were significantly different between Alzheimer’s disease elderly and normal elderly（t=-5.269,P〈0.01）.The urine formaldehyde concentration of patients group（0.26±0.22） was significantly higher than that of normal group（0.04±0.02）.Conclusion The level of endogenous formaldehyde higher than normal may be one of the pathogenic factors for sporadic Alzheimer’s disease.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2010年第8期721-722,共2页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词
阿尔茨海默病
甲醛
尿
神经元
色谱法
高压液相
Alzheimer disease
formaldehyde
urine
neurons
chromatography,high pressure liquid
