摘要
目的加强新生儿重症监护病房(NICU)的医院感染监测,为NICU医院感染预防和控制措施的制定提供理论依据。方法收集医院2007年4月-2008年12月,NICU收治的患儿473例,采集相应的临床标本,进行病原菌的分离,并对结果进行分析研究。结果 NICU收治的患儿473例,其中男性266例,占56.24%,女性207例,占43.76%;共分离病原菌178株,革兰阳性球菌53株,其中凝固酶阴性葡萄球菌居多,共24株,占13.48%;革兰阴性杆菌125株,其中肺炎克雷伯菌居多,36株,占20.22%;17株金黄色葡萄球菌中,MRSA7株,占金黄色葡萄球菌的41.18%;凝固酶阴性葡萄球菌和金黄色葡萄球菌均对哌拉西林/他唑巴坦和头孢哌酮/舒巴坦敏感,耐药率分别为20.83%、29.17%和29.41%、29.41%,未发现耐万古霉素葡萄球菌;肺炎克雷伯菌和大肠埃希菌对亚胺培南100.00%敏感,其次对头孢哌酮/舒巴坦较敏感,耐药率分别为13.89%和16.67%。结论强化手卫生,增强医务人员对手卫生的依从性,可减少医务人员手携带多药耐药菌的程度,有效降低NICU内患儿发生医院感染的危险性。
OBJECTIVE To enhance the surveillance and control of nosocomial infection in neonatal intensive care units（NICU）,and to provide basis for prevention and control measures against nosocomial infection.METHODS The clinical specimens were collected from admitted to the NICU 473 cases of children from Apr 2007 to Dec 2008,the pathogenic bacteria were isolated,and the results were analyzed.RESULTS A total of 473 cases of children were studied,266 cases of boys,accounted for 56.24%,and girls 207 cases,accounted for 43.76%.A total of 178 strains of pathogens were isolated,the most were coagulase-negative staphylococci（CNS）,accounted for 13.48% of the isolates.And 125 strains of Gram-negative bacilli were isolated,of which the majority of Klebsiella pneumoniae,accounted for 20.22%.MRSA accounted for 41.18%.The resistance rates of CNS and Staphylococcus aureus to the piperacillin/tazobactam and cefoperazone/sulbactam was 20.83%,29.17% and 29.41%,29.41%,respectively.The vancomycin-resistant Staphylococcus were not found.K.pneumoniae and Escherichia coli were 100% sensitive to imipenem,and more sensitive to cefoperazone/sulbactam,the drug resistance rates were 13.89% and 16.67%,respectively.CONCLUSION Strengthening the hand hygiene and enhancing its compliance of the medical staff would greatly reduce the level of multiple drug-resistant bacteria carried by medical staff and effectively reduce the risk of nosocomial infection in NICU.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第16期2467-2469,共3页
Chinese Journal of Nosocomiology
关键词
新生儿重症监护病房
医院感染
监测
预防策略
Neonatal intensive care units
Nosocomial infection
Surveillance
Prevention strategies
