摘要
目的探讨慢性乙型肝炎患者血清中自身抗体的变化情况。方法收集慢性乙型肝炎患者180例血清标本,测定抗核抗体(ANA)和可提取性核抗原(ENA)抗体;另取100例健康体检者作为正常对照,ANA和ENA的检测采用间接免疫荧光法。结果慢性乙型肝炎患者ANA的检出率分别为15.6%高于正常对照组的3.0%(P<0.05);慢性乙型肝炎患者ENA的阳性率为7.2%,阳性主要有nRNP/Sm、SS-A、Scl-70、Jo-1、dsDNA等类型。结论慢性乙型肝炎患者血清自身抗体显著高于正常人。
OBJECTIVE To investigate the autoantibodies in patients with chronic hepatitis B.METHODS Both antinuclear antibody（ANA） and anti-extracted nuclear antigen（ENA） antibody were detected in 180 patients with chronic hepatitis B.Another 100 cases of healthy persons collected as the control group.RESULTS The detected rate of ANA patients with chroic hepatitis were significantly higher（P0.05） in B（15.6%） than that（3.0%）of the control group.The positive rate of anti-ENA antibody was 7.2% in the patients with hepatitis B.The main types for positive results were nRNP/Sm,SS-A,Scl-70,Jo-1,and ds-DNA,and so on.CONCLUSIONS The autoantibodies in serum of patients with chronic hepatitis B are significantly higher than that in healthy persons.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第15期2214-2215,共2页
Chinese Journal of Nosocomiology
