摘要
目的总结与功效和毒性相关的吴茱萸化学成分研究现状,明确吴茱萸的功效成分与毒性成分,为进一步研究吴茱萸化学成分与功效、毒性之间的相关性提供文献依据和思路。方法对近20年来国内外发表的相关文献进行分析、整理和归纳。结果生物碱是吴茱萸的主要化学成分和活性成分,是吴茱萸发挥功效的主要物质基础;药典和文献记载吴茱萸有小毒,而关于吴茱萸化学成分毒性的研究报道还很少,对吴茱萸的毒理学研究还不够深入。结论吴茱萸是否还含有其他发挥功效的物质基础和化学成分?吴茱萸产生毒性的物质基础和化学成分是什么?以及吴茱萸功效化学成分与毒性化学成分之间的相关性和吴茱萸化学成分与功效、毒性之间的"量-效关系"、"量-毒关系"如何,有待进一步深入研究,以期为吴茱萸的质量标准规范化研究和临床安全合理用药提供试验依据。
Objective By combing pertinent literature,and summarizing the current states of chemical composition of evodiamine related with its efficacy and toxicity,to identify its effective and toxical composition,offer the accordance and research ideas for further research on the relationship between efficacy,toxicity and chemical composition of evodiamine.Methods The related references in recent 10 years both at home and abroad about evodiamine were analyzed,collated and summarized.Results Alkaloids are the main chemical constituents and active ingredients,and are the main material basis for efficacy in evodiamine;evodiamine has small toxicity documented in pharmacopoeia and literature,but the research reports related to the toxicity of chemical constituents are very few and the research about toxicology of evodiamine is still not deep enough.Conclusion There is or not other effective chemical composition in evodiamine,and what is the toxical chemical composition in evodiamine,and the relevance between effective chemical composition and toxical chemical composition,and the ＂dose-efficacy＂ and ＂dose-toxicity＂relationship between efficacy,toxicity and chemical composition in evodiamine,and so on;they are to be further deep study and to provide experimental evidence for the optimization、security and quality control、safety and rational use in clinic.
出处
《中国药物警戒》
2010年第8期482-485,共4页
Chinese Journal of Pharmacovigilance
基金
国家重点基础研究发展计划(973)中医基础理论专项资助项目(项目编号:2009CB522802)
山东省科技平台建设项目课题(课题编号:2008GG2NS02021)
关键词
吴茱萸
化学成分
功效
毒性
evodiamine
chemical composition
efficacy
toxicity
