摘要
为探讨阿霉素心肌病的发病机理，采用大鼠阿霉素心肌病模型（ＳＤ大鼠１０只），于实验第２、４、６周末，分别采血检测血清一氧化氮（ＮＯ）、丙二醛（ＭＤＡ）含量，并于实验６周后对大鼠心肌进行病理形态学观察。结果：实验中不同时期所测ＡＤＲ组血清ＮＯ、ＭＤＡ值，均较正常对照组明显升高（Ｐ＜０．０１），且随观察时间的延长而增加，并与病理改变相一致。提示：ＡＤＲ可使大鼠诱生ＮＯ和促进氧自由基的释放。
The present study was undertaken to examine the mechanisms of cardiomyopathy induced by adriamycin (ADR) in rats.Serum content of nitric oxide (NO) and malondialdehyde (MDA) of model rats ( n]=10) were measured respectively after two-week,four-week and six-week experiment.Myocardial histopathological observation was performed after six-week experiment and compared with control group. Results: Serum content of NO and MDA increased gradually in ADR group,which were significantly higher than that in control group ( P <0.01) and identical to myocardial histopathological observations. Conclusions: ADR may make the rats induce NO,release Oxygen free radical and lead to cardiomyopathy.
出处
《南通医学院学报》
1999年第2期160-161,共2页
ACTA Academiae Medicinae Nantong
