摘要
用离体豚鼠气管条，探讨侧柏叶乙酸乙酯提取物对气管平滑肌作用。结果表明，侧柏叶乙酸乙酯提取物能抑制乙酰胆碱、氯化钾所致气管平滑肌收缩，而且能使乙酰胆碱收缩气管平滑肌的量效曲线右移，并抑制最大效应，其作用为剂量依赖性，提示侧柏叶乙酸乙酯提取物松驰气管平滑肌作用机制可能与影响Ｃａ^（２＋）的跨膜转运有关。
The mechanism of antiasthmatic action of the ethyl acetate soluble fraction of extract of Platycladus orientalis (L. ) Franco was studied with smooth muscle of isolated guinea pig trachea. The results indicated that P. orientalis could significantly Inhibit the contraction of isolated guinea pig trachea preparations induced by acetylcholine (ACh) and KCI. P. orientalis shifted the dose response curves for ACh nonparallelly to right and depress their maximal response, in a dose dependent manner. These results suggested that the antagonistic effects of P. orientalis on smooth muscle contraction induced by the two agonists may be mainly related to action of P. orientalis in blocking calcium channel of tracheal smooth muscle.
出处
《中草药》
CAS
CSCD
北大核心
1999年第4期278-279,共2页
Chinese Traditional and Herbal Drugs
关键词
侧柏叶提取物
气管平滑肌
跨膜转运
Platycladus orientalis (L. ) Franco calcium channel blockers guinea pig tracheal strips
