摘要
大鼠腹主动脉部分狭窄５周后，形成实验性心肌肥厚模型，心肌和左心室重量明显增加，心肌过氧化脂质（ＬＰＯ）含量显著增加，ＳＯＤ活性下降，心肌和主动脉Ｃａ^（２＋）含量明显增加。给槲皮素７５、１５０ ｍｇ／ｋｇ后均能明显降低心肌和左心室重量，降低心肌ＬＰＯ含量，增加ＳＯＤ活性，降低心肌和主动脉Ｃａ^（２＋）的含量，提示槲皮素抗心肌肥厚作用与清除氧自由基和钙拮抗有关。
Cardiac hypertrophy models of rat were prepared by coarctation of abdominal aorta for 5 weeks, which resulted in a significant increase of myocardium and left ventricular weights. Lipid peroxidation (LPO) products and calcium contents of myocardium and aorta were also increased with decrease of superoxide dismutase (SOD) activity. After treatment with quercetin 75 mg/kg and 150 mg/kg for 5 weeks, the myocardium and left ventricular weights decreased significantly LPO products and calcium content of myocardium and aorta were lowered with increase of SOD activity These results suggested that the effects of quercetin for the prevention of cardiac hypertrophy may be related to its ability to scavenge oxygen free radicals and antagonize calcium ions.
出处
《中草药》
CAS
CSCD
北大核心
1999年第4期275-277,共3页
Chinese Traditional and Herbal Drugs
关键词
槲皮素
心肌肥厚
氧自由基
钙
心脏负荷
quercetin cardiac hypertrophy
oxygen free radical
calcium antagonist
