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新辅助化疗TT_(hp)C方案在局部晚期乳腺癌患者中的应用效果分析 被引量：5

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摘要 目的:探讨新辅助化疗TThpC方案在局部晚期乳腺癌患者中的应用效果。方法:对71例行新辅助化疗TThpC方案的局部晚期乳腺癌患者的临床资料进行总结分析。71例患者中ⅢA期42例,ⅢB期2例,ⅢC期27例。采用TThpC方案(艾素100mgd1,吡柔比星60mgd1,环磷酰胺0.8gd1,21d为1个周期),化疗4～6个周期后观察疗效。结果:本组患者新辅助化疗后临床完全缓解者有23例,占32.4%;部分缓解者有32例,占45.1%;病情稳定者有16例,占22.5%;疾病进展者为0;病理学完全缓解者有1例,占1.4%。68例(95.8%)重获根治手术机会,2例(2.8%)重获保乳手术机会,中位随访时间28个月,总生存率为98.6%(70/71),无瘤生存率为97.2%(69/71)。结论:紫杉类药物与蒽环类药物联合新辅助化疗TThpC方案对局部晚期乳腺癌的效果肯定,毒副反应临床可以耐受,值得临床应用和推广。
作者 陈馨 王雪晨 袁毅路 姚永忠 桑剑峰 苏磊
机构地区 南京大学医学院附属鼓楼医院普外科
出处 《实用医学杂志》 CAS 北大核心 2010年第15期2798-2800,共3页 The Journal of Practical Medicine
关键词 乳腺肿瘤 TThpC方案 艾素 吡柔比星 环磷酰胺
分类号 R737.9 [医药卫生—肿瘤]
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参考文献10

  • 1Cady B.Breast cancer in the third millennium[J].J Surg Oncol,2001,77(4):225-232.
  • 2Lara F,Delagarza J,Bamirez T,et al.High pathological complete response(PCR)afar neoadjuvant chemotherapy with doxoruhicin and docetaxel in locally advanced breast cancer[J].Proc Am Soc Clin Oncol,2000(19):126a.
  • 3张斌.乳腺癌的新辅助化疗[J].中华肿瘤杂志,2003,25(3):209-211. 被引量：72
  • 4Henderson I C,Berry D,Demetri G D,et al.Improved outcomes from adding sequential paclitaxel but not from eslating doxorubicin dose in an adjuvant chemotherapy regimen for patients with node positive primary breast cancer[J].J Clin Oncol,2003,21(6):976-983.
  • 5Shimizu T.Weekly administration of paclitaxel and pirarubicine for recurrent breast cancer[J].Gan To Kagaku Ryoho,2003,30(1):105-109.
  • 6Garces C A,Cance W G.Neoadjuvant chemotherapy of breast cancer[J].Am Surg,2004,70(7):565-569.
  • 7王雪晨,姚永忠,钱晓萍,刘宝瑞.新辅助化疗对乳腺癌骨髓微转移的影响[J].江苏医药,2006,32(2):134-135. 被引量：10
  • 8郝春芳,江泽飞,宋三泰.乳腺癌新辅助化疗若干问题的讨论[J].国外医学（肿瘤学分册）,2003,30(2):116-118. 被引量：20
  • 9Hutcheon A W,Ogston K N,Heys S D,et al.Primary chemotherapy in the treatment of breast cancer:significantly enhanced clinical and pathological response with docetaxel[J].Proc Am Soc Clin Oncol,2000(19):83.
  • 10Cance WG,Carey L A,Calvo B F,et al.Long-termoutcome of neoacljuvant therapy for locally advanced brast carcinoma:effective clinical downstaging allows breast preservation and predicts out-standing local control and survival[J].Ann Surg,2002,236(3):295-303.

二级参考文献43

  • 1Ozbas S,Dafydd H, Purushotham AD. Bone marrow micrometastasis in breast cancer. Br J Surg, 2003,90: 290-301.
  • 2Montemurro F, Aglietta M. Selected highlights from the 26th San Antonio Breast Cancer Symposium. December 3-6,2003,San Antonio,TX, USA, Expert Opin Pharmacother, 2004, 5:981-989.
  • 3Fisher ER, Wang J, Bryant J, et al. Pathobiology of preoperative chemotherapy: findings from the National Surgical Adjuvant Breast and Bowel (NSABP) protocol B-18 [J]. Cancer, 2002,95(4):681-695.
  • 4van der Hage JA, van de Velde CJ, Julien JP, et al. Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treatment of Cancer trial 10902[J]. J Clin Oncol, 2001,19(22): 4224-4237.
  • 5Newman LA, Buzdar AU, Singletary SE, et al. A prospective trial of preoperative chemotherapy in resectable breast cancer: predictors of breast-conservation therapy feasibility [ J ]. Ann Surg Oncol,2002,9(3) : 228-234.
  • 6Ezzat AA, Ibrahim EM, Ajarim DS, et al . High complete pathological response in locally advanced breast cancer using paclitaxel and cisplatin [J]. Breast Cancer Res Treat, 2000,62(3):237-244.
  • 7Buzdar AU, Singletary SE, Valero V, et al. Evaluation of paclitaxel in adjuvant chemotherapy for patients with operable breast cancer:preliminary data of a prospective randomized trial [ J ]. Clin Cancer Res, 2002,8(5): 1073-1079.
  • 8Smith IC, Heys SD, Hutcheon AW, et al. Neoadjuvant chemotherapy in breast cancer: significantly enhanced response with docetaxel[J]. J Clin Oncol, 2002,20(6): 1456-1466.
  • 9NSABP. The effect on primary tumor response of adding sequential Taxotere to Adriamycin and cyclophosphamide: Preliminary results from NSABP Protocol B-27 [ J ].Breast Cancer Res Treat,2001,69:210a.
  • 10Wenzel C, Locker GJ, Pluschnig U, et al. Phase Ⅰ/Ⅱ trial of weekly epidoxorubicin and docetaxel (wED) in the neoadjuvant and palliative treatment of patients with breast cancer [J]. Cancer Chemother Pharmacol, 2002,50(2): 155-159.

共引文献95

同被引文献72

  • 1王涛,江泽飞,宋三泰,刘晓晴,于静新,刘芳,闫敏.单药赫赛汀~治疗复发转移性乳腺癌[J].中华肿瘤杂志,2004,26(7):430-432. 被引量：25
  • 2田丽军,徐兵河.托瑞米芬和他莫昔芬对血脂影响的对比研究[J].实用癌症杂志,2004,19(5):520-522. 被引量：7
  • 3Lewis S. Do endocrine treatments for breast cancer have a negative impact on lipid profiles and cardiovascular risk in postmenopausal women [J]. Am Heart J, 2007,153 (2): 182-188.
  • 4Buzdar A,Howell A, Cuzick J, et al. Comprehensive side- effect profile of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: long-term safety analysis of the ATAC trial [J]. Lancet Oneol, 2006,7(8) :633-43.
  • 5Liu C L, Yang T L. Sequential changes in serum triglyceride levels during adjuvant tamoxifen therapy in breast cancer patients and the effect of dose reduction [J]. Breast Cancer Res Treat, 2003,79 ( 1 ) : 11-16.
  • 6Hozumi Y, Kawano M, Saito T, et al.Effect of tamoxifen on serum lipid metabolism [J]. J Clin Endocrinol Metab, 1998, 83(5) : 1633-1535.
  • 7Kataja V, Hietanen P, Joensuu H, et al. The effects of adjuvant anastrozole, exemestane, tamoxifen, and toremifene on serum lipids in postmenopansal women with breast cancer-a randomized study [J]. Breast Cancer Res Treat, 2002,76(Suppl 1 ) : S156.
  • 8Erkkola R, Mattila L, Powles T, et al.Bone mineral density and lipid changes during 5 years of follow-up in a study of prevention of breast cancer with toremifene in healthy, high- risk pre-and post-menopansal women [J]. Breast Cancer Res Treat, 2005,93(3) :277-287.
  • 9Wasan K M, Goss P E, Pritchard P H, et al. The influence of letrozole on serum lipid concentrations in postmenopausal women with primary breast cancer who have completed 5 years of adjuvant tamoxifen (NCIC CTG MA.17L) [J]. Ann Oncol, 2005, 16(5) :707-715.
  • 10Thurlimann B, Keshaviah A, Coates A S, et al. A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer [J]. N Engl J Med, 2005,353(26):2747-2757.

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实用医学杂志
2010年 第15期

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