摘要
目的：探讨米非司酮对胎肝细胞超微结构的影响。方法：将中孕期引产的病例分为米非司酮组与对照组，每组各５例，孕周为１８～２１周孕。米非司酮组在引产前６ｈ服用１５０ｍｇ米非司酮，然后行水囊引产术，对照组则只行水囊引产术。胎儿娩出后，取肝组织进行样品制备以供电镜观察。结果：与正常的胎肝细胞对照，米非司酮引产的肝细胞胞质内脂滴、自噬泡及含铁体较为常见，糖原颗粒局部减少或缺如，肝细胞间成红细胞极为常见，其它细胞器则未见明显变化。结论：米非司酮可造成胎肝组织缺氧，因此引起的糖酵解尚可勉强维持肝细胞的能量需求。
Aim: Influence of mifepristone on the ultrastructure of human fetal liver cells was investigated. Methods:\ 10 pregnant women (range of gestational age from 18 to 21 weeks) with indications of pregnancy termination were recuited and divided into 2 groups. Mifepristone group ( n= 5), 150 mg mifepristone per os was given six hours before labor was induced, control group ( n =5), labor induction was performed by extra-amniotic insertion of waterbag only. Immediately after delivery of fetus, liver tissue was acqiured and prepared for electron microscopic examination. Results:\ In comparison with control group, the fetal hepatocytes of mifepristone group contained more lipid droplets, autophagosomes and siderosomes. Glycogen particles were scarce or completely lacked in some places. Erythroblasts were frequently encountered among the hepatocytes. Other organelles such as mitochondria and rough endoplasmic reticulum revealed no noticeable morphological changes. Conclusion:\ These results indicated that under the effects of mifepristone, human fetal liver is hypoxic and its energy reqiurement can be supplied by anerobic glycolysis.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
1999年第2期1-5,共5页
Journal of Jinan University(Natural Science & Medicine Edition)
