摘要
目的:探讨米非司酮用于中期引产对胎儿脐血染色体稳定性的影响。方法:选择中期引产对象60例,随机分成研究组和对照组各30例,研究组口服米非司酮150mg,服药后6h行水囊引产;对照组行常规水囊引产。娩出胎儿后,立即取母血及脐血培养,姐妹染色单体交换率(SCE)分化及分析。结果:研究组母血及脐血SCE频率分别为(4.16±0.98)次和(3.74±1.31)次,对照组母血及脐血分别为(3.66±1.20)次和(3.23±0.76)次,两组比较差异无显著性(P>0.05)。结论:米非司酮用于中期引产并未引起胎儿脐血染色体稳定性的改变。
Objective: To study the effect of Mifepristone on chromosome stability of fetus umbilical blood in intermediate induced labor. Methods: 60 women were divided into the study group with 30 persons and the control group with 30 ones. The women in the study group took orally 150 mg Mifepristone in six hours before induced labor, while those in the control group received conventional induced labor. Maternal peripheral blood and umbilical blood was acquired for SCE investigation. Results : The frequency of SCE of maternal blood and umbilical blood in control group was (3.66+1.20) and (3.23±0.76), respectively, while that was (4.16± 0.98)and(3.74±1.31) in the study group. There was no significant difference between two groups(P>0.05). Conclusion: Mifepristone has no effect on the chromosome stability of fetus umbilical blood.
出处
《中国计划生育学杂志》
2004年第6期360-361,共2页
Chinese Journal of Family Planning
