摘要
【目的】探讨低剂量呋喃唑酮、阿莫西林和奥美拉唑三联治疗Hp阳性消化性溃疡的疗效及安全性。【方法】选择符合条件的96例Hp阳性的消化性溃疡患者，随机分为两组，治疗组：48例，口服呋喃唑酮100mg：阿莫西林1000mg和奥美拉唑20mg；对照组：48例，口服阿莫西林1000mg；克拉霉素500mg和奥美拉唑20mg；两组均为每天2次，抗生素疗程1周。8d后继续服用奥美拉唑20mg，每天1次，连服3周。患者在停药后4周行胃镜检查和快速尿素酶试验，观察溃疡愈合情况和Hp根除率及副作用的发生率。【结果】治疗组失访2例，对照组失访1例，根据意向治疗分析（1TT）和按治疗方案分析（PP），治疗组和对照组的Hp根除率分别是85．4％VS87．5％和89．1％VS89．4％，两组的溃疡愈合率分别是87．5％VS 91．7％and91．3％VS93．6％，两组Hp根除率和溃疡愈合率比较差异均无显著性（P〉0．05）；两组的不良反应发生率分别是8．7％和6．4％，两组比较差异无显著性（P〉0．05）。【结论】低剂量呋喃唑酮、阿莫西林和奥美拉唑三联疗法治疗Hp阳性消化性溃疡，溃疡愈合率和Hp根除率高，副作用小，价格低廉，是一种安全有效的治疗方法。
[Objective]To investigate the efficacy and safety of low-dose triple therapy（furazotidone, amoxicillin and omeprazole） for Hp-positive peptic ulcer. [Methods] Ninety-six patients with Hp-positive peptic ulcer were randomly divided into treatment group（ n =48） and control group（ n =48）. The treatment group were given furazolidone（100mg）, amoxieillin（1000mg） and omeprazole（20mg） twice a day for a week. The control group were given amoxicillin（1000mg）, clarithromycin（500mg） and omeprazole（20mg ） twice a day for a week. And then both groups were treated with omeprazol（20mg/d） alone for another three weeks. Four weeks later, the gastroscopy and rapid urease test were performed to evaluate the rates of ulcer healing, the rates of Hp eradication and the rates of side effect. [Results] Two patients were lost to be followed up in treatment group while one patient was lost in control group. According to the intention to treat analysis（ITT） and perprotocol analysis（PP）, the rates of Hp eradication were 85.4% vs 8：7.5% and 89.1% vs 89.4%, respectively. The rates of ulcer healing were 87.5% vs 91.7% and 91.3% vs 93.6%, respectively. The rates of the side effects were 8.7% and 6.4%, respectively. There was no significant difference between two groups（ P 〉0.05）. [Conclusion] Low-dose furazolidone, amoxi-cillin and omeprazole triple therapy have the high eradication rates of Hp and the high rates of ulcer healing. It is a safe and effective treatment for Hp-positive peptic ulcer with fewer side effects and lower cost.
出处
《医学临床研究》
CAS
2010年第7期1301-1303,共3页
Journal of Clinical Research
