摘要
目的 考察朱砂七总蒽醌对亚硝化反应的抑制活性.方法 以硫酸、氯仿为溶剂从朱砂七中提取总蒽醌,在模拟人体胃液的条件下,采用分光光度法测定朱砂七蒽醌（ZSQEK）对亚硝酸盐的清除能力和对亚硝胺合成的阻断能力.结果 ZSQEK对亚硝胺合成的阻断能力和对亚硝酸钠的清除能力与浓度呈相关关系,最大清除率为53.5%,最大阻断率为71.3%.结论 ZSQEK对亚硝化反应具有较强的抑制作用.
Objective To study inhibitory activity of anthraquinone in Polygonum Cillinerve（Nakai） Ohwi （anthraquinone in PCO） to nitrosation. Methods Anthraquinone was extracted from Polygonum Cillinerve（Nakai） Ohwi with sulfuric acid and chloroform as solvents. The capability of scavenging sodium nitrite and disconnecting nitrosamine synthesis with anthraquinone in PCO were determined by spectrophotometry under simulated human gastric juice. Results Both the sodium nitrite scavenging rate and the nitrosamine synthesis disconnecting rate showed the positive correlation with the concentration of anthraquinone in PCO. The strongest capability of scavenging sodium nitrite was 53.5%, and the strongest capability of disconnecting nitrosamine synthesis was 71.3%. Conclusion Anthraquinone in PCO had strong capability of scavenging sodium nitrite and disconnecting nitrosamine synthesis.
出处
《国际中医中药杂志》
2010年第4期355-356,共2页
International Journal of Traditional Chinese Medicine
关键词
朱砂七蒽醌
亚硝酸钠
亚硝胺
Polygonum Cillinerve （Nakai） Ohwi Anthraquinone Sodium nitrite Nitrosamine
