摘要
目的 探索肺炎支原体所致下呼吸道感染的免疫学发病机制。方法 采用顺序饱和液相竞争放射免疫分析法及夹心酶免疫放射分析法对３０ 例肺炎支原体所致下呼吸道感染患儿血清进行了肿瘤坏死因子（ Ｔ Ｎ Ｆ） － α和白细胞介素－ ８（ Ｉ Ｌ－ ８） 的检测。结果 肺炎支原体所致下呼吸道感染患儿血清中 Ｔ Ｎ Ｆ－ α及 Ｉ Ｌ－ ８ 水平均明显高于健康儿童； Ｔ Ｎ Ｆ－ α和 Ｉ Ｌ－ ８ 升高呈正相关。结论 Ｔ Ｎ Ｆ－ α在肺炎支原体所致下呼吸道感染中起着重要作用，也是 Ｉ Ｌ－ ８ 升高的重要促进因子。
Objective To investigate the immunopathological mechanism of LRTI caused by Mycoplasma pneumonia. Methods Serum tumor necrosis factor-α (TNF-α) and interleukin-8 ( IL- 8) from 30 patients with LRTI caused by Mycoplasma pneumonia , were measured with sequence saturated solution competitive radioimmunoassay and sandwich ELISA. Results The level of serum TNF-α and IL-8 of patients suffering from LRTI caused by Mycoplasma pneumonia were magnificently higher than that of healthy children. Meanwhile, a positive relationship between serum TNF-α and IL-8 was noticed. Conclusion TNF-α plays an important role in LRTI caused by Mycoplasma pneumonia , and serves the key factor to the elevation of IL-8.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
1999年第1期50-52,共3页
Chinese Journal of Epidemiology
