摘要
目的：探讨穿山甲对大鼠离体心脏功能和体外血小板聚集性的影响。方法：制备大鼠离体工作心脏、观察ＫＨ灌注液中加入穿山甲前后的心功能指标变化，并设立对照组；采用１５名冠心病患者的静脉血制备富血小板血浆和贫血小板血浆，每一标本分成三部分供三组使用：穿山甲组、阿司匹林组和对照组，以ＡＤＰ诱导血小板聚集。结果：大鼠离体工作心脏灌注液中加入穿山甲液后，ＬＶＳＰ，＋ｄｐ／ｄｔｍａｘ和ＣＯ显著增加，－ｄｐ／ｄｔｍａｘ，ＬＶＥＤＰ及ＣＦ无显著变化，这些指标在对照组中无显著变化。与对照组比较，穿山甲和阿司匹林组的血小板聚集百分率显著降低。结论：穿山甲增强心肌收缩功能、有正性肌力作用。
Objective:To study the effect of Squama Manitis(S.M.)on cardiac function and platelet aggregation in vitro.Method:Isolated working rat hearts were prepared,and cardiac performance was measured before and after adding S.M. in the Krebs Hensleit(K H) perfusion buffer.Controls with K H buffer were also investigated. Rich platelet plasma and Poor platelet plasma were centrifuged from the blood of 15 patients with coronary heart disease.Each sample was divided into three parts for use by three groups:control,group of S.M. and group of aspirin.Platelet aggregation was stimulated by adenosine diphosphate.Result:LVSP,+dP/dt max and CO of isolated working rat hearts were significantly increased after treating with S.M. liquor.S.M. had no obvious effect on dP/dt max and LVEDP.These parameters did not change significantly in the control.Percentages of platelet aggregation were significantly lower in the group of S.M. and the group of aspirin as compared with the control.Conclusion:S.M. increases cardiac systolic function,has positive inotropic effect on myocardium and inhibits platelet aggregation.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1999年第1期51-52,共2页
China Journal of Chinese Materia Medica
关键词
穿山甲
离体工作心脏
中药
药理
血小板聚集
Squama Manitis
isolated working heart
cardiac systolic and diastolic function
platelet aggregation
