摘要
目的:探讨乌司它丁对重度烧伤患者脏器功能的保护作用及其机制。方法:80例重度烧伤患者随机分为对照组及治疗组,对照组给与乌司它丁10000U/d干预,2周后检测两组患者血清IL-6、TNF-α、肾功能及肝功能变化。结果:对照组血清IL-6、TNF-α表达水平高于对照组,血清BUN、Cr水平高于对照组,ALT、AST高于对照组,CHE低于对照组。结论:乌司它丁能够对重度烧伤患者脏器功能起到保护作用,其机制可能同抑制烧伤后体能炎症介质释放有关。
Objective：To investigate the protective effect of ulinastatin to internal organs functions on patients with major burn and found its reason.Methods：80 patients with major burn were randomly divid into Control groups（CG） and therapy group（TG）,the paitients in TG received additional drug trcatmant with 10 000U ulinastatin/d in two wecks,the concentrution of TNF-α and IL-6 in serum were measure,liver and kidney functions were detected in two groups after two weeks.ResUlts：In Comparisons with TG,the concentration of TNF-α and IL-6 in serum were higher in CG,and the concentration of BUN,Cr, ALT and AsT was higher and CHE was lower in CG.Conelusion：Ulinastatin could protect internal organs functions on patients with major burn,which maybe was correlative with decreasing expression of inflammation mediators.
出处
《中国医药导刊》
2010年第7期1186-1187,共2页
Chinese Journal of Medicinal Guide
关键词
严重烧伤
乌司它丁
炎症介质
脏器功能
肿瘤坏死因子Α
白细胞介素6
Major bum
ulinastatin
Inflmmation mediators
Internai organs functions
Tumor necrosis factora
Interleukin 6
