黄体酮对创伤性脑损伤后炎症因子的抑制作用的研究
被引量:4
摘要
创伤性脑损伤(Traumatic brain injury,TBI)后的炎症反应是导致继发性脑损害的主要原因之一。在TBI发生后早期,即有大量致炎细胞因子的释放和免疫细胞的激活。免疫细胞的激活,反过来又会导致自由基和更多的炎症介质释放。无论这种炎症级联反应由何种因素启动,对炎症反应的抑制都可以减轻脑水肿,减少神经元的死亡或胶质增生。
出处
《中华神经外科杂志》
CSCD
北大核心
2006年第3期186-189,共4页
Chinese Journal of Neurosurgery
参考文献10
-
1Morganti-Kossmann MC,Rancan M,Otto Ⅵ,et al.Role of cerebral inflammation after traumatic brain injury:a revisited concept.Shock,2001,16:165-177.
-
2Shear DA,Galani R,Hoffman SW,et al.Progesterone protects against necrotic damage and behavioral abnormalities caused by traumatic brain injury.Exp Neurol,2002,178:59-67.
-
3Djebaili M,Guo Q,Pettus EH,et al.The neurosteroids progesterone and allopregnanolone reduce cell death,gliosis,and functional deficits after traumatic brain injury in rats.J Neurotrauma,2005,22:106-118.
-
4Golarai G,Greenwood AC,Feeney DM,et al.Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury.J Neurosci,2001,21:8523-8537.
-
5Chen J,Sanberg PR,Li Y,et al.Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats.Stroke,2001,32:2682-2688.
-
6Lenzlinger PM,Morganti-Kossmann MC,Laurer HL,et al.The duality of the inflammatory response to traumatic brain injury.Mol Neurobiol,2001,24:169-181.
-
7Ghosh S,Karin M.Missing pieces in the NF-kappaB puzzle.Cell,2002,109:S81-96.
-
8Kalkhoven E,Wissink S,van der Saag PT,et al.Negative interaction between the RelA (p65) subunit of NF-kappaB and the progesterone receptor.J Biol Chem,1996,271:6217-6224.
-
9Stein DG,Hoffman SW.Estrogen and progesterone as neuroprotective agents in the treatment of acute brain injuries.Pediatr Rehabil,2003,6:13-22.
-
10Monnet FP,Mahe V,Robel P,et al.Neurosteroids,via sigma receptors,modulate the [3H] norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.Proc Natl Acad Sci U S A,1995,92..3774-3778.
同被引文献43
-
1曹德晨,只达石,张赛.雌激素和孕激素的神经保护作用[J].中国脑血管病杂志,2005,2(2):90-92. 被引量:6
-
2陈罡,杭春华,史继新,王汉东,张鑫,李劲松,印红霞.人脑外伤后皮层核因子-κB的表达[J].中华创伤杂志,2006,22(8):609-612. 被引量:8
-
3潘德生,刘伟国,杨小锋.黄体酮对大鼠脑损伤后脂质过氧化的抑制作用[J].中华创伤杂志,2006,22(11):866-867. 被引量:4
-
4肖国民,危静,吴正虎,王卫民,姜启周,程军,陆峰,吴建跃,徐海松,方蓉.孕酮治疗急性重型颅脑损伤疗效和作用机制的临床研究[J].中华外科杂志,2007,45(2):106-108. 被引量:11
-
5Stein DG. Brain damage, sex hormones and recovery: a new role for progesterone and estrogen? Trends Neurosci, 2001, 24 (7): 386 - 391.
-
6Wright DW, Kellermann AL, Hertzberg VS, et al. ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury. Ann Emerg Med, 2007, 49(4) :391 -402.
-
7Feeney DM, Boyeson MG, Linn RT, et al. Responses to cortical injury: I. Methodology and local effects of contusions in the rat. Brain Res, 1981, 211(1) :67 -77.
-
8Djebaili M, Hoffman SW, Stein DG. Allopregnanolone and progesterone decrease cell death and cognitive deficits after a contusion of the rat pre-frontal cortex. Neuroscience, 2004, 123(2) : 349 - 359.
-
9Goss CW, Hoffman SW, Stein DG. Behavioral effects and anatomic correlates after brain injury: a progesterone dose - response study. Pharmacol Biochem Behav, 2003, 76(2):231 -242.
-
10Hang CH, Shi JX, Tian J, et al. Effect of systemic LPS injection on cortical NF - kappaB activity and inflammatory response following traumatic brain injury in rats. Brain Res, 2004, 1026( 1 ) :23 -32.
引证文献4
-
1陈罡,杭春华,史继新,王汉东,印红霞.黄体酮对大鼠脑外伤后皮层Toll样受体和核因子-kB表达的影响[J].中华创伤杂志,2008,24(2):112-115.
-
2魏山坡,司道文,杨鹏,陈广,姚秀婷,李云,徐胜,董伟,裴斐,黄佳伟,张宇新.创伤性脑损伤后孕酮促进神经功能的实验研究[J].实用医药杂志,2014,31(5):434-435. 被引量:3
-
3董明昊,葛学诚,出良钊,冯鲁乾,陈益民,刘健.创伤性脑损伤后性激素变化对预后的影响[J].中华创伤杂志,2014,30(9):887-889. 被引量:1
-
4魏山坡,李翀瑶,司道文.孕酮对大鼠脑损伤后脑水肿的影响及机制[J].中国老年学杂志,2015,35(21):6017-6019. 被引量:1
二级引证文献5
-
1甘宁,刘思思,张晖.以颅脑创伤为主的男性创伤患者早期血清孕酮的变化特点与临床意义[J].中西医结合心血管病电子杂志,2016,4(26):73-74.
-
2王智华,林庆喜,黄平香,张扬丽,曾钦林,陈红琴,李静梅.血清CNP、IGF-Ⅱ、ET、NSE和S100B在颅脑外伤中的临床应用研究[J].国际检验医学杂志,2017,38(21):2984-2987. 被引量:11
-
3靳子娟,李婵,陶柏妮,李云,杨鹏.脊髓损伤后孕酮保护作用研究[J].神经损伤与功能重建,2017,12(5):415-417. 被引量:2
-
4金孟浩,吴丽君,孙孟坊,王丰,吴挺前,徐强.高压氧联合黄体酮治疗中重度创伤性脑损伤后血性激素的变化及预后分析[J].中国医院统计,2017,24(5):329-331. 被引量:2
-
5李婵,李云,靳子娟,陶柏妮,杨鹏.孕酮对兔脊髓急性缺血再灌注损伤后细胞凋亡的影响[J].中国临床神经外科杂志,2017,22(11):767-770.
-
1冀建超.雄激素β_4降低内毒素诱发的脓毒性休克死亡率并下调炎症介质释放[J].中国危重病急救医学,2003,15(9):534-534.
-
2於国军,王一兵,封必钊.乌司它丁对重度烧伤患者脏器功能的保护作用研究[J].中国医药导刊,2010,12(7):1186-1187.
-
3江稳强,陈纯波,王桥生,孙诚,曾文新,曾红科.血小板计数在预警脓毒症致器官功能障碍中的意义[J].中华内科杂志,2009,48(8):676-677. 被引量:5
-
4张洪亮,王文波,李明宇,李进取,史雪峰.致炎细胞因子在骨性关节炎病理生理中的作用[J].现代生物医学进展,2014,14(5):989-992. 被引量:21
-
5冯英凯,杨庆华,徐剑铖,钱桂生.高迁移率族蛋白-1在急性肺损伤发病中的作用[J].国外医学(临床生物化学与检验学分册),2004,25(6):547-550.
-
6赵娇,王海滨,张冬青,王云云.新型生物标志物在烧伤脓毒症诊断中的意义[J].感染.炎症.修复,2015,16(2):125-128. 被引量:1
-
7高建军,李敏敏,王林华,张彬,赵宏胜.乌司他丁治疗脓毒症34例效果观察[J].交通医学,2014,28(2):129-130. 被引量:5
-
8潘利伟,孙来芳,郭蕾.乌司他丁治疗感染性休克的临床疗效观察[J].实用医学杂志,2005,21(11):1210-1211. 被引量:19
-
9王立义,张晓.甲状腺激素在创伤后MODS患者中的变化及临床意义[J].第四军医大学学报,2009,30(12):1094-1094. 被引量:1
-
10姜云云,赵海滨,叶光明,周永华,陈云红,吴渊文.复方紫黄乳膏对大鼠深Ⅱ度烧伤创面的愈合作用[J].中药药理与临床,2013,29(5):132-134. 被引量:5