摘要
目的:探讨复方苦参素注射液联合FOLFOX-4方案对结直肠癌术后患者6周期辅助化疗的临床疗效。方法:采用复方苦参素注射液联合FOLFOX-4方案对52例(B组)结直肠癌术后患者辅助化疗,与单纯FOLFOX-4方案化疗组48例(A组)对照。结果:B组患者体质量增加率、生活质量提高明显(P<0.01),并且恶心、呕吐、肝功能损害、粒细胞减少等不良反应明显较A组降低(P<0.01)。结论:复方苦参素注射液联合FOLFOX-4辅助化疗方案能显著减轻结直肠癌术后患者的化疗不良反应,提高生存质量,为下一步接受更多的化疗周期,延长生存期创造有利条件。
OBJECTIVE To evaluate the effect of 6 cycles of compound matrine injection in combination with FOLFOX-4 ad juvant chemotherapy for sub operation colorectal cancer patients. METHODS 52 sub-operation colorectal cancer patients （group B） received compound matrine injection in combination with FOLFOX-4 adjuvant chemotherapy, and another 48 pa tients（group A） received chemotherapy only. RESULTS The rate of increase on weight and quality of life in group B increased significantly （P〈0. 01 ）. And the incidences of nausea, vomiting, hepatic injury and the reduction of granulocyte were signifi cantly lower in group B （P〈0. 01 ）. CONCLUSION The addition of compound matrine injection in FOLFOX-4 adjuvant chemotherapy can significantly lighten the toxic side effects of chemotherapy, enhance the quality of life and create advantageous chances for patients to receive more chemotherapy cycles and extendable life.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2010年第14期1215-1217,共3页
Chinese Journal of Hospital Pharmacy
