摘要
目的观察慢性乙型肝炎患者应用丹参注射液和异甘草酸镁治疗后肝功能和肝纤维化指标的改善情况。方法将80例慢性乙型肝炎患者，随机分为丹参组40例，异甘草酸镁组40例，在常规保肝治疗基础上，两组分别加用丹参注射液和异甘草酸镁注射液治疗，疗程均为30d。观察两组患者治疗前、后的肝功能和肝纤维化指标[血清透明质酸酶（HA）、层黏连蛋白（LN）、Ⅳ型胶原（Ⅳ-C）]的变化。结果治疗后丹参注射液和异甘草酸镁均可明显改善慢性乙型肝炎患者的肝功能，异甘草酸镁组较丹参组为优（P〈0．05）。丹参组肝纤维化指标较治疗前有下降（P〈0．05）；异甘草酸镁组肝纤维化指标与治疗前比较差异无统计学意义（P〉0．05）；两组治疗后的肝纤维化指标比较，差异有统计学意义（P〈0．05）。结论丹参注射液改善肝纤维化的疗效优于异甘草酸镁，而异甘草酸镁改善肝功能的疗效优于丹参注射液。
Objective To observe the change of liver function and liver fibrosis indexes of the chronic hepatitis B patients that were treated by Danshen injection（DI） and magnesium isoglycyrrhizinate（MI）. Methods 80 chronic hepatitis B patients based on the conventional treatment were randomly divided into DI group（dO patients） and MI group（dO patients）. The two groups were used with DI and MI injection for 30 days respectively and then, the levels of liver function and serum hepatic fibrosis（ HA, LN, Ⅳ-C） were detected and compared before and after treatment. Results Treatment by DI and MI could both improve liver function significantly, the effect of MI group was better than DI group（ P 〈 0.05）. Moreover, in improving serum hepatic fibrosis, the effect of DI group was better than MI group （P 〈 0.05 ）. Conclusions The efficacy of the improvement to hepatic fibrosis DI is better than MI, while in improvement of liver function MI is superior to DI.
出处
《国际流行病学传染病学杂志》
CAS
2009年第3期158-159,共2页
International Journal of Epidemiology and Infectious Disease
关键词
肝纤维化
丹参注射液
异甘草酸镁
肝炎
乙型
慢性
Liver fibrosis
Danshen injection
Magnesium isoglycyrrhizinate
Hepatitis B, chronic
