摘要
目的了解阿立哌唑与齐拉西酮治疗精神分裂症的疗效及不良反应的差异。方法检索国内关于阿立哌唑与齐拉西酮对照研究治疗精神分裂症的文献,用固定效应模型法的方差倒置法;对查阅到的7篇进行评估。结果阿立哌唑与齐拉西酮比较疗效无显著性差异(P>0.05),齐拉西酮组发生肌强直、食欲减退不良反应较阿立哌唑组多,有显著性差异(P<0.05)。结论阿立哌唑与齐拉西酮的疗效相当;但阿立哌唑不良反应的发生率较低。
Objective To study the difference in therapeutic effects and side effects between aripiprazole and ziprasidone in the treatment for schizophrenia. Methods A total of 7 paper about control study comparing aripiprazole with ziprasidone in treatment of schizophrenia retrieved form domestic were subjected to variance inversion methods of fixed effects model. Results There was no significant difference on clinical efficacy between aripiprazole group and ziprasidone group （ P 〉 0.05 ）. The incidences of adverse reactions such as rigidity decrease of appetite in ziprasidone group were significantly higher than in aripiprazole group （P 〈 0. 05 ）. Conclusion Aripiprazole is as effective as but less toxic than ziprasidone for the treatment of schizophrenia.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2010年第7期529-531,共3页
The Chinese Journal of Clinical Pharmacology
基金
重庆市卫生局科研课题基金资助项目(2008-2-386)
