摘要
目的探讨齐拉西酮治疗老年期痴呆精神行为异常的临床疗效及对糖脂代谢的影响。方法将118例老年期痴呆精神行为异常患者随机分为利培酮组与齐拉西酮组,分别接受利培酮及齐拉西酮口服治疗,疗程3个月。采用痴呆病理行为评定量表(BEHAVE-AD)及副反应量表(TESS)评分2组临床疗效及不良反应,并比较2组治疗前后糖脂代谢指标的改变。结果治疗后3个月2组BEHAVE-AD评分显著下降(P<0.05),但组间比较差异无统计学意义(P>0.05);利培酮组体质量增加、月经异常及泌乳等不良反应发生率显著高于齐拉西酮组(P<0.05);治疗后利培酮组空腹血糖、胆固醇(TC)、低密度脂蛋白(LDL-C)及胰岛素均显著高于齐拉西酮组(P<0.05)。结论齐拉西酮与利培酮治疗老年期痴呆精神行为异常疗效相当,但齐拉西酮不良反应少,对糖脂代谢无明显影响。
Objective To explore the effect of ziprasidone on senile dementia complicated with psychiatric and behavioral symptoms and the influence on glucose and lipid metabolism .Methods 118 cases of senile dementia complicated with psychiat-ric and behavioral symptoms were randomly divided into risperidone group and ziprasidone group .The course of treatment was 3 months .BEHAVE-AD and TESS scales were used to evaluate the effectiveness and the rate of side effect .The indexes of glu-cose and lipid metabolism were compared between two groups .Results After treatment ,BEHAVE-AD scores greatly decreased in two groups （P 0 .05）;Weight gain ,lactation and menstruation abnormality rates in risperidone group were much higher than those in ziprasidone group （P〈0 .05）;Compared with ziprasidone group ,fasting blood glucose ,TC ,LDL-C and insulin of risperidone group greatly increased （P〈0 .05） .Conclusion ziprasidone and risperidone have equivalent clinical efficacy in treatment of senile dementia＆nbsp;complicated with psychiatric and behavioral symptoms ,while ziprasidone has less side effects and influence on glucose and lipid metabolism .
出处
《中国实用神经疾病杂志》
2014年第12期49-50,共2页
Chinese Journal of Practical Nervous Diseases
关键词
老年痴呆
精神行为异常
齐拉西酮
利培酮
Senile dementia
Psychiatric and behavioral disorders
Ziprasidone
Risperidone
