摘要
目的：研究碱性纤维生长因子（bFGF）、转化生长因子－β1（TGF－β1）及其受体在骨肉瘤中的表达特点，以及它们与肿瘤内微血管密度和病人预后的关系。方法：应用免疫组化和形态计量检测80例骨肉瘤微血管密度（MVD），bFGF、TCF－β1及其受体的表达，并应用COX比例风险模型检测上述因素与预后的关系。结果：80例骨肉瘤中，bFGF／FGFr阳性46例（57．5％），TGF－β1／TGFβ（RI）阳性31例（38．8％）。bFGF、TGF－β1与其受体表达具有一致性，并且与MVD值显著相关。COX比例风险模型分析结果显示MVD和bFGF、TGF－β1均是影响骨肉瘤的重要因素（P＜0．05）。结论:bFGF和TGF－β1是骨肉瘤血管生成的重要因子，并通过促进血管生成影响病人的预后，可能成为判估骨肉瘤病人预后的重要指标.
Objective: To investigate the expression of angiogenic factors basic fibroblast growth factor (bFGF) and transforming growth factor (TGF) －β1 in osteosarcoma, as well as their association with neovascularization and prognosis.Method: The expression of bFGF .TGF－β1 and their receptors, as well as intratumoral microvessel count (MVD) were detected in 80 osteosaroomeas by immunohistochemical staining and morphometry. The relationship between the angiogenic factors expression and prognosis was evaluated by a multivariate analysis using COX proportion hazard model. Results: Among 80 cases Of osteosarcoma, 46 cases were positive for bFGF/hFCFr (57. 5% ), 31 cases for TGF FI /TGF p (RI) (38. 8% ), respectively. The expression of hFGF and TGF β1 was coordinate with its receptors, moreover, correlated with the microvessel density (MVD). The MVD and bFGF. TGF－β1 were important indicator to predict the prognosis of patients with osteosarcoma by the COX proportion hazard model analysis. Conclusions: The angiogenic factors bFGF and TGF－β1 are involved in the angiogenesis of osteosarcoma, furthermore angiogeneiss influences the prognosis, also it may be useful to evaluated the prognosis of patients with osteosarcoma.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1999年第2期142-145,共4页
Chinese Journal of Cancer
基金
全军"九五"青年基金
