摘要
目的：探讨食管鳞癌DNA含量与临床特点及预后之间关系。方法：应用流式细胞分析术（FCM）和图像细胞分析术（ICM）对41例食管鳞癌石蜡标本进行DNA含量测定，回顾性分析其预后指标。结果：FCM和ICM测定的DNA含量表明：DNA倍体与淋巴结转移、临床病理分期、组织分化程度有密切关系（P＜0．05）；DNA倍体与预后有密切关系（P＜0．01）。且两种方法测定的DNA含量组方图相似。两者测定均为二倍体的肿瘤患者7例，均生存5年以上，符合率100％；均为异倍体者29例，符合率87．8％。结论：两者均可成为食管鳞癌患者预后的检测指标。
Purpose: To determine the Correlation of DNA content with clinicopathologic features and prognosis of esophageal squamous cell carcinoma. Methods: Using Flow Cytometry (FCM) and Image Cytometry (ICM), an retrospective study was performed on 41 paraffinembedded samples of esophageal squamous cell carcinoma. Results: The DNA content of esophageal cancer was measured by FCM and ICM. The results showed that 11 cases (26. 8% ) were diploidy and the other 30 cases were aneuploidy. A close correlation was observed among the DNA ploidy status, lymph node metastasis,TNM staging and degree of the cancer cell differentiation (P < 0. 05 ). DNA ploidy status was also found to be related with prognosis of patients (P < 0. 01 ). The five year survival rate of patients with diploidy tumors was significantly higher than that of patients with aneuploidy tumors. Seven cases of diploid and 29 cases of aneuploid were measured by both methods.The seven patients with diploidy tumors all survived for more than five years. Conclusions: DNA content measured by FCM and ICM were the prognostic factors for patients with esophageal squamous cell carcinoma.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1999年第2期126-128,共3页
Chinese Journal of Cancer
