摘要
目的:观察补充外源性抗氧化剂对急性心脑血管意外老年病人血浆谷胱甘肽过氧化物酶(GSH-Px)的活性、维生素A(VitA)、维生素C(VitC)、维生素E(VitE)和硒(Se)水平的影响。方法:对105例急性心脑血管意外老年病人随机分为试验组(加用抗氧化剂)和对照组(服用安慰剂)。两组病人均每天服用1次,连续6周。两组病人在治疗前、治疗后3周和6周,清晨空腹采取肘静脉血3 ml。检测血浆GSH-Px活性、VitA、VitC、VitE和Se的水平变化。结果:治疗3周和6周后,试验组病人血浆GSH-Px活性,VitC、VitE和Se水平较对照组明显升高(P<0.05)。试验组病人治疗6周后VitA水平较对照组明显升高(P<0.05)。结论:对急性心脑血管意外老年病人补充外源性抗氧化剂,可在短时间内增加血浆VitA、VitC、VitE、Se的含量和GSH-Px的活性。
Objective： To investigate whether a drink with essential vitamins and minerals during cardio-and cerebro-vascular accident illness can improve glutathione peroxidase activity and levels of vitamin A,vitamin C and vitamin E in older people.Methods： A six-week randomized,double blind,placebo controlled intervention study was made.Cardio-and cerebro-vascular accident ill older people（≥65 years older） randomly assigned to receive either a multivitamin/mineral or placebo drink daily for six weeks.Biological markers of vitamin and trace element and free radical parameters were measured initially,the third week,and the sixth week after supplementation.Results： Changes in plasma vitamin C,vitamin E,selenium and glutathione peroxidase activity were significantly different between two groups both after 3 weeks and 6 weeks（P〈0.05）.However,there was no difference between two groups in vitamin A after 3 weeks.Conclusion： Supplementation with antioxidants in cardio-and cerebro-vascular accident illness people can raise plasma level of vitamin A,vitamin C,vitamin E,selenium and glutathione peroxidase activity.
出处
《肠外与肠内营养》
CAS
北大核心
2010年第4期218-220,223,共4页
Parenteral & Enteral Nutrition
关键词
谷胱甘肽过氧化酶
抗氧化剂
急性心脑血管意外
老年病人
Antioxidant supplements
Glutathione peroxidase activity
Cardio-and cerebro-vascular accident older people
