摘要
观察胃癌组织中生长抑素（ＳＳ）表达与表皮生长因子受体（ＥＧＦＲ）表达的相互关系，探讨其抑癌的可能机制。方法应用免疫组化ＬＳＡＢ法及即用型ＳＰ法，对１４７例各组织学类型胃癌中ＳＳ及ＥＧＦＲ的表达进行观察比较，并对其中１２７例患者进行预后随访。结果胃癌中ＳＳ阳性表达率为２５．７％。ＳＳ阳性及ＳＳ阴性两组胃癌ＥＧＦＲ的表达差异有显著意义（Ｐ＜０．０１）。ＳＳ阳性胃癌组ＥＧＦＲ的表达明显减少。伴有ＳＳ阴性表达的ＥＧＦＲ阳性胃癌预后尤其差。结论ＳＳ及ＥＧＦＲ在人体胃癌组织中的表达有一定拮抗性。ＳＳ阴性的ＥＧＦＲ阳性胃癌预后更差。ＳＳ的抑癌机制之一可能是干扰了生长因子的合成。
Objective To study the correlation in gastric carcinoma (GC) between the expression ofsomatostatin (SS) and epidermal growth factor receptor (EGFR). Method Expression of SS and EGFR in147 cases of GC were comparatively observed by using immunoh istoc hemistry. Among them, 127 cases werefollowed up. Result The positive expression of SS in GC was 25.7%. There was significant difference in expression of EGFR between two groups in SS positive and SS negative GC groups (P<0.01). Expression ofEGFR in SS positive GC group was obviously decreased. The GC patients with positive EGFR had shorter survival time than those with negative EFGR (P<0.01). The shortest survival rate was found in the patientswiTh GC having positive EGFR and negative SS. Conclusion There was certain antagonist between the expression of SS and EGFR in human GC. One of the mechanisms of inhibitory tumor by SS might be contributed to the interference with the synthesis of autocrine growth factors by tumor cells and with transmission of intracellular signals that regulate cell growth.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1999年第2期126-127,共2页
Chinese Journal of Experimental Surgery
关键词
生长抑素
胃肿瘤
表皮生长因子
受体
Somatostatin, Epidermal growth factor receptor ,Stomach neoplasms,Immunohistochemistry
