摘要
用放射免疫法定量检测胃癌病人血清（３０例），唾液（３０例）和尿（３２例）中人类表皮生长因子（ｈＥＧＦ），并与正常健康人进行对照比较。结果表明，胃癌病人唾液ｈＥＧＦ和血清ｈＥＧＦ均显著高于对照组（２７３±１０８ｐｍｏｌ／Ｌ与１１９±６１ｐｍｏｌ／Ｌ，Ｐ＜０．０１；２１７±９３ｐｍｏｌ／Ｌ与１８３±７４ｐｍｏｌ／Ｌ，Ｐ＜０．０５），但胃癌病人尿ｈＥＧＦ与对照组比较差异无显著性（Ｐ＞０．０５）。按胃癌ＴＮＭ分期比较，Ⅲ期以上胃癌病人唾液中ｈＥＧＦ含量显著高于Ⅱ期以下胃癌病人（Ｐ＜０．０１）。但血清和尿ｈＥＧＦ含量在此两组病人间则差异无显著性。按肿瘤生长部位分组，胃体癌与胃窦癌之间差异亦无显著性。
Human epidermal growth
factor(hEGF)in serum(n=30),saliva(n=30)and urine((n=32)of patients with gastric carcinoma were
assessedquantitatively with method of RIA,and 30 health adults served as controls. The
resultsshowed: hEGF in saliva and serum of the patients were increased significantlycompared
with those of controls(273±l08 pmol/L and ll9±61 pmol/L,P<0.0l;217±93 pmol/L and l83±74
pmol/L,P<0.05), whereas hEGF in urine of these patientswere not different from controls
(P>0.05).According to TNM classification for gastriccarcinoma, hEGF in saliva of the cancer
patients with stageⅢ,Ⅳ were significantlyhigher than that of the patients with stage Ⅰ,Ⅱ(P<
0.01),but hEGF in serum andurine were not different in these two groups of patients.Also, there
were no differencebetween patients with carcinoma in gastric antrum and in gastric body.To the
author’sopinion, hEGF plays an important role in the growth of gastric cancer.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1996年第2期79-81,共3页
Chinese Journal of Digestion
关键词
胃肿瘤
血液
尿液
唾液
表皮生长因子
Gastric neoplasm Epidermal growth factor Blood UrineSaliva
