摘要
观察促甲状腺素释放激素（ＴＲＨ）对肺挫伤合并休克的效果与血浆及挫伤肺组织中一氧化氮（ＮＯ）、内皮素（ＥＴ）和血管紧张素转换酶（ＡＣＥ）的变化。方法采用生物撞击机撞击家兔右侧胸壁及股动脉放血的肺挫伤合并休克模型。实验分两组：对照组家兔３６只，给予生理盐水；实验组家兔１８只，给予ＴＲＨ治疗。结果ＴＲＨ治疗组各时相点平均动脉压及动脉血气明显改善，ＴＲＨ组０．５小时挫伤肺组织中ＮＯ／ＥＴ儿乎等于正常水平、４小时血浆挫伤肺组织明显高于撞前水平（Ｐ＜０．０１），并显著高于对照组（Ｐ＜０．０５）。结论ＴＲＨ能改善肺挫伤合并休克家兔的休克和肺功能。
Objective To investigate the effects of new antishock drug, thyrotropin-releasing hormone(TRH), on pulmonary contusion (PC) with shock and changes in nitric oxide (NO)/endothelin (ET).Methods The model of PC with shock was established by striking on lateral-right chest wall of rabbits bybioimpact machine and femoral artery bleeding. Fifty-four rabbits were divided into two groups: 18 rabbits inTRH group was given TRH, while 36 rabbits in control group given the same volume saline. Results Themean arterial pressure was elevated and the arterial gases improved in TRH group at each time point. The NOlevels in plasma and tissue of the contused lung in TRH group were much higher than in control group (P<0.01). The NO/ET was almost equal to normal level and at the 4th h point was much higher than normal levelof preimpact. Conclusion TRH can improve the shock and the pulmonary function in the rabbits of PC withshock.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1999年第2期121-123,共3页
Chinese Journal of Experimental Surgery
关键词
肺挫伤
休克
一氧化氮
内皮素
TRH
Pulmonary contusion, Shock, Nitric oxide ,Endothelin ,Thyrotropin-releasing hormone
